Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 2342389..2343497 Replicon chromosome
Accession NZ_CP126128
Organism Desemzia incerta strain EGm139

Toxin (Protein)


Gene name MNTss Uniprot ID A0A2H4HI44
Locus tag QNK01_RS11375 Protein ID WP_029170889.1
Coordinates 2342389..2343258 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag QNK01_RS11380 Protein ID WP_000205227.1
Coordinates 2343273..2343497 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNK01_RS11340 (QNK01_11340) 2337741..2338139 - 399 WP_188205206.1 cytidine deaminase -
QNK01_RS11345 (QNK01_11345) 2338193..2339128 - 936 WP_284029424.1 aminoglycoside phosphotransferase family protein -
QNK01_RS11350 (QNK01_11350) 2339166..2339756 - 591 WP_188205204.1 GrpB family protein -
QNK01_RS11355 (QNK01_11355) 2339776..2339994 - 219 WP_188205203.1 hypothetical protein -
QNK01_RS11360 (QNK01_11360) 2340076..2340714 - 639 WP_188205202.1 hypothetical protein -
QNK01_RS11365 (QNK01_11365) 2340778..2341641 - 864 WP_284029425.1 aminoglycoside 6-adenylyltransferase -
QNK01_RS11370 (QNK01_11370) 2341674..2342408 - 735 WP_284029426.1 class I SAM-dependent methyltransferase -
QNK01_RS11375 (QNK01_11375) 2342389..2343258 - 870 WP_029170889.1 nucleotidyltransferase domain-containing protein Toxin
QNK01_RS11380 (QNK01_11380) 2343273..2343497 - 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
QNK01_RS11385 (QNK01_11385) 2343640..2344461 - 822 Protein_2167 recombinase zinc beta ribbon domain-containing protein -
QNK01_RS11390 (QNK01_11390) 2345149..2345952 - 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
QNK01_RS11395 (QNK01_11395) 2346006..2347490 - 1485 WP_002294513.1 ABC-F type ribosomal protection protein Lsa(E) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island ant(6)-Ia / lnu(B) / lsa(E) / msr(D) / mef(A) - 2339166..2358455 19289


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-114)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32820.25 Da        Isoelectric Point: 4.9564

>T282649 WP_029170889.1 NZ_CP126128:c2343258-2342389 [Desemzia incerta]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIMKDTEHGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAETY
PNALQKSLVNFFMFEAGFSLMFVKANSGTDDKYYIAGHVFRIVSCLNQVLFACNNAYCINEKKAIKLLETFEHKPEKYTE
KVNHIFEVLGISLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT282649 WP_000205227.1 NZ_CP126128:c2343497-2343273 [Desemzia incerta]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2H4HI44

Antitoxin

Source ID Structure

References