282648

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 171813..172387 Replicon chromosome
Accession NZ_CP126128
Organism Desemzia incerta strain EGm139

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QNK01_RS00795 Protein ID WP_284029557.1
Coordinates 171813..172151 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag QNK01_RS00800 Protein ID WP_284029558.1
Coordinates 172145..172387 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNK01_RS00775 (QNK01_00775) 167990..169576 - 1587 WP_284029553.1 Mur ligase family protein -
QNK01_RS00780 (QNK01_00780) 169830..170231 + 402 WP_284029554.1 nucleoside-diphosphate kinase -
QNK01_RS00785 (QNK01_00785) 170311..171075 - 765 WP_284029555.1 SDR family oxidoreductase -
QNK01_RS00790 (QNK01_00790) 171205..171387 - 183 WP_284029556.1 hypothetical protein -
QNK01_RS00795 (QNK01_00795) 171813..172151 - 339 WP_284029557.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QNK01_RS00800 (QNK01_00800) 172145..172387 - 243 WP_284029558.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QNK01_RS00805 (QNK01_00805) 173474..174664 + 1191 WP_000997694.1 IS256-like element ISLgar5 family transposase -
QNK01_RS00810 (QNK01_00810) 174799..176988 + 2190 WP_000470931.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(M) - 108393..327644 219251
- flank IS/Tn - - 173474..174664 1190


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-105)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13050.19 Da        Isoelectric Point: 9.6251

>T282648 WP_284029557.1 NZ_CP126128:c172151-171813 [Desemzia incerta]
MVKQGDIIKMNLDPKQGHEQQGYRPYICLNYHRVSDYANIAVFAPILNAERNYPLYVPLKGTKSSGKVLLDQLVTIDYNT
RKYQYVESVPEKLTDELLMKVKVIFQKNEKIK

Download         Length: 339 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9185.46 Da        Isoelectric Point: 4.5158

>AT282648 WP_284029558.1 NZ_CP126128:c172387-172145 [Desemzia incerta]
MIQLPIKRWGNSHAIRLPKSILEALEAEKDDELNVEVVNHSIVLTKAEKELTFEGLFKDYSGELFASEIQTIFPEGNEKW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References