Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 243248..243884 Replicon chromosome
Accession NZ_CP126116
Organism Metabacillus sp. CT-WN-B3

Toxin (Protein)


Gene name mazF Uniprot ID A0A2N5FBL1
Locus tag QLQ22_RS01355 Protein ID WP_029286376.1
Coordinates 243534..243884 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A2N5FBR6
Locus tag QLQ22_RS01350 Protein ID WP_029286378.1
Coordinates 243248..243529 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ22_RS01330 (QLQ22_01330) 239278..239871 - 594 WP_223439017.1 rhomboid family intramembrane serine protease -
QLQ22_RS01335 (QLQ22_01335) 239974..240339 + 366 WP_284015867.1 holo-ACP synthase -
QLQ22_RS01340 (QLQ22_01340) 240485..241495 + 1011 WP_223439019.1 outer membrane lipoprotein carrier protein LolA -
QLQ22_RS01345 (QLQ22_01345) 241920..243101 + 1182 WP_223439020.1 alanine racemase -
QLQ22_RS01350 (QLQ22_01350) 243248..243529 + 282 WP_029286378.1 YlcI/YnfO family protein Antitoxin
QLQ22_RS01355 (QLQ22_01355) 243534..243884 + 351 WP_029286376.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QLQ22_RS01360 (QLQ22_01360) 244022..244858 + 837 WP_223439021.1 STAS domain-containing protein -
QLQ22_RS01365 (QLQ22_01365) 244855..245220 + 366 WP_101569209.1 STAS domain-containing protein -
QLQ22_RS01370 (QLQ22_01370) 245223..245624 + 402 WP_070878720.1 anti-sigma regulatory factor -
QLQ22_RS01375 (QLQ22_01375) 245636..246646 + 1011 WP_223439022.1 PP2C family protein-serine/threonine phosphatase -
QLQ22_RS01380 (QLQ22_01380) 246709..247041 + 333 WP_223439023.1 anti-sigma factor antagonist -
QLQ22_RS01385 (QLQ22_01385) 247038..247520 + 483 WP_223439024.1 anti-sigma B factor RsbW -
QLQ22_RS01390 (QLQ22_01390) 247486..248274 + 789 WP_070878724.1 RNA polymerase sigma factor SigB -
QLQ22_RS01395 (QLQ22_01395) 248274..248873 + 600 WP_223439025.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13036.06 Da        Isoelectric Point: 4.8781

>T282645 WP_029286376.1 NZ_CP126116:243534-243884 [Metabacillus sp. CT-WN-B3]
MIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDSKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10572.01 Da        Isoelectric Point: 7.0156

>AT282645 WP_029286378.1 NZ_CP126116:243248-243529 [Metabacillus sp. CT-WN-B3]
VSESSATTEILIRLPQALVSELDGLVKQENGNRSELIYQATKMYIRERKKRQIRESMRRGYMEMAKINLNIASEAFQAES
EADHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N5FBL1

Antitoxin

Source ID Structure
AlphaFold DB A0A2N5FBR6

References