Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 242381..243017 Replicon chromosome
Accession NZ_CP126115
Organism Neobacillus sp. YX16

Toxin (Protein)


Gene name mazF Uniprot ID A0A1H0EHG9
Locus tag QNH48_RS01265 Protein ID WP_034673264.1
Coordinates 242667..243017 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag QNH48_RS01260 Protein ID WP_095251323.1
Coordinates 242381..242662 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH48_RS01240 (QNH48_01240) 238719..239312 - 594 WP_283953439.1 rhomboid family intramembrane serine protease -
QNH48_RS01245 (QNH48_01245) 239414..239764 + 351 WP_095251318.1 holo-ACP synthase -
QNH48_RS01250 (QNH48_01250) 239895..240905 + 1011 WP_283953440.1 outer membrane lipoprotein carrier protein LolA -
QNH48_RS01255 (QNH48_01255) 241032..242195 + 1164 WP_283953441.1 alanine racemase -
QNH48_RS01260 (QNH48_01260) 242381..242662 + 282 WP_095251323.1 YlcI/YnfO family protein Antitoxin
QNH48_RS01265 (QNH48_01265) 242667..243017 + 351 WP_034673264.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QNH48_RS01270 (QNH48_01270) 243206..245380 + 2175 WP_283953442.1 Tex family protein -
QNH48_RS01275 (QNH48_01275) 245631..245744 - 114 WP_095251326.1 cortex morphogenetic protein CmpA -
QNH48_RS01280 (QNH48_01280) 245837..246310 + 474 WP_283953443.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13034.09 Da        Isoelectric Point: 5.1961

>T282644 WP_034673264.1 NZ_CP126115:242667-243017 [Neobacillus sp. YX16]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALRVSIGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10739.32 Da        Isoelectric Point: 6.4751

>AT282644 WP_095251323.1 NZ_CP126115:242381-242662 [Neobacillus sp. YX16]
VSESGATTEILVKLPQHLLTELDGFVKLENVNRSEFIYQATKMYLRERKKRQIRESMRRGYMEMAMINLSIASEAFQAEF
EAEHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H0EHG9

Antitoxin

Source ID Structure

References