282642

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2915111..2915730 Replicon chromosome
Accession NZ_CP126113
Organism Siminovitchia fortis strain XLM16

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QNH23_RS14640 Protein ID WP_120070206.1
Coordinates 2915111..2915437 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag QNH23_RS14645 Protein ID WP_235870277.1
Coordinates 2915437..2915730 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH23_RS14620 (QNH23_14620) 2910767..2912005 - 1239 WP_120070213.1 Zn-dependent hydrolase -
QNH23_RS14625 (QNH23_14625) 2912178..2913563 + 1386 WP_120070211.1 sigma 54-interacting transcriptional regulator -
QNH23_RS14630 (QNH23_14630) 2913680..2914792 + 1113 WP_283903040.1 agmatine deiminase -
QNH23_RS14640 (QNH23_14640) 2915111..2915437 - 327 WP_120070206.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QNH23_RS14645 (QNH23_14645) 2915437..2915730 - 294 WP_235870277.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QNH23_RS14650 (QNH23_14650) 2916056..2916184 - 129 WP_268920374.1 hypothetical protein -
QNH23_RS14655 (QNH23_14655) 2916202..2917716 - 1515 WP_120070203.1 osmoprotectant update ABC transporter permease/substrate-binding subunit OpuFB -
QNH23_RS14660 (QNH23_14660) 2917709..2918659 - 951 WP_120070201.1 ABC transporter ATP-binding protein -
QNH23_RS14665 (QNH23_14665) 2918807..2919592 + 786 WP_120070198.1 TIGR00266 family protein -
QNH23_RS14670 (QNH23_14670) 2919618..2920268 - 651 WP_120070195.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin

SpoVT-AbrB domain

(22-67)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11894.69 Da        Isoelectric Point: 7.1342

>T282642 WP_120070206.1 NZ_CP126113:c2915437-2915111 [Siminovitchia fortis]
MSVPDRGDLVYVNFNPQTGHEQAGNRPGIVLSPKEFNQVTGFASICLITKTARGWGFEVKLPEGLAFQGVILTDQVKNLD
WAARNLKVKGKAPDELVEECLAKIHTFL

Download         Length: 327 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10916.47 Da        Isoelectric Point: 5.2082

>AT282642 WP_235870277.1 NZ_CP126113:c2915730-2915437 [Siminovitchia fortis]
MEEDTRSSGNEVDHMTIPTTVQKWGNSLAVRIPKDVAERINIHQGSEMEISVTGKGVIMLVPKKQPKKYSLEELLAKCTP
ENRHEEIDFGVEGKELI

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References