Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2699784..2700420 Replicon chromosome
Accession NZ_CP126113
Organism Siminovitchia fortis strain XLM16

Toxin (Protein)


Gene name mazF Uniprot ID A0A429X0R4
Locus tag QNH23_RS13675 Protein ID WP_018709209.1
Coordinates 2699784..2700134 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag QNH23_RS13680 Protein ID WP_018709208.1
Coordinates 2700139..2700420 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH23_RS13645 (QNH23_13645) 2694964..2695293 - 330 WP_120075882.1 STAS domain-containing protein -
QNH23_RS13650 (QNH23_13650) 2695371..2696381 - 1011 WP_120075884.1 PP2C family protein-serine/threonine phosphatase -
QNH23_RS13655 (QNH23_13655) 2696396..2696797 - 402 WP_120075886.1 anti-sigma regulatory factor -
QNH23_RS13660 (QNH23_13660) 2696802..2697158 - 357 WP_120075887.1 STAS domain-containing protein -
QNH23_RS13665 (QNH23_13665) 2697155..2697991 - 837 WP_120075889.1 STAS domain-containing protein -
QNH23_RS13670 (QNH23_13670) 2698296..2699594 - 1299 WP_144463775.1 IS1380 family transposase -
QNH23_RS13675 (QNH23_13675) 2699784..2700134 - 351 WP_018709209.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QNH23_RS13680 (QNH23_13680) 2700139..2700420 - 282 WP_018709208.1 YlcI/YnfO family protein Antitoxin
QNH23_RS13685 (QNH23_13685) 2700858..2702024 - 1167 WP_120075928.1 alanine racemase -
QNH23_RS13690 (QNH23_13690) 2702212..2703963 - 1752 WP_120075929.1 adenine deaminase -
QNH23_RS13695 (QNH23_13695) 2703992..2705359 - 1368 WP_120075932.1 NCS2 family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2698296..2699594 1298


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12947.99 Da        Isoelectric Point: 5.1663

>T282641 WP_018709209.1 NZ_CP126113:c2700134-2699784 [Siminovitchia fortis]
MVVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDSKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDEEMMEKVDDALQISLGLIAF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10758.26 Da        Isoelectric Point: 5.7557

>AT282641 WP_018709208.1 NZ_CP126113:c2700420-2700139 [Siminovitchia fortis]
VSESSATTEIIIRLPQQLLAELDGFVEQENVNRNEFIYRATKMYIRERKKRHIVESMRRGYMEMAKINLAIASEAIQAEY
EAEHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A429X0R4

Antitoxin

Source ID Structure

References