Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 279840..280479 Replicon chromosome
Accession NZ_CP126112
Organism Peribacillus simplex strain WH6

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag QNH37_RS01455 Protein ID WP_034306610.1
Coordinates 280129..280479 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag QNH37_RS01450 Protein ID WP_034306380.1
Coordinates 279840..280121 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH37_RS01430 (QNH37_01430) 275974..276564 - 591 WP_283900215.1 rhomboid family intramembrane serine protease -
QNH37_RS01435 (QNH37_01435) 276673..277023 + 351 WP_283900216.1 holo-ACP synthase -
QNH37_RS01440 (QNH37_01440) 277268..278272 + 1005 WP_283900217.1 outer membrane lipoprotein carrier protein LolA -
QNH37_RS01445 (QNH37_01445) 278495..279679 + 1185 WP_283900218.1 alanine racemase -
QNH37_RS01450 (QNH37_01450) 279840..280121 + 282 WP_034306380.1 antitoxin EndoAI Antitoxin
QNH37_RS01455 (QNH37_01455) 280129..280479 + 351 WP_034306610.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QNH37_RS01460 (QNH37_01460) 280894..281721 + 828 WP_048682050.1 RsbT co-antagonist protein RsbRA -
QNH37_RS01465 (QNH37_01465) 281724..282080 + 357 WP_076373142.1 STAS domain-containing protein -
QNH37_RS01470 (QNH37_01470) 282084..282485 + 402 WP_048682056.1 anti-sigma regulatory factor -
QNH37_RS01475 (QNH37_01475) 282495..283505 + 1011 WP_283900219.1 PP2C family protein-serine/threonine phosphatase -
QNH37_RS01480 (QNH37_01480) 283565..283897 + 333 WP_098372176.1 anti-sigma factor antagonist -
QNH37_RS01485 (QNH37_01485) 283894..284367 + 474 WP_098372177.1 anti-sigma B factor RsbW -
QNH37_RS01490 (QNH37_01490) 284345..285133 + 789 WP_283900221.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12955.06 Da        Isoelectric Point: 7.2029

>T282640 WP_034306610.1 NZ_CP126112:280129-280479 [Peribacillus simplex]
IVVKRGDVYFADLSPVVGSEQGGTRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEPMMQKVNEALQISLGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10713.13 Da        Isoelectric Point: 5.9054

>AT282640 WP_034306380.1 NZ_CP126112:279840-280121 [Peribacillus simplex]
VSESSATREILIRLPQNFLTELDGYASEENVNRSEFIYRATKMYLRERKKKEFRESMKRGYIEMAAINLTIASEAFQAEF
EAGHCVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References