Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 218042..218678 Replicon chromosome
Accession NZ_CP126109
Organism Fictibacillus enclensis strain TL11

Toxin (Protein)


Gene name pemK Uniprot ID I8UKL4
Locus tag QNH15_RS01250 Protein ID WP_007200228.1
Coordinates 218328..218678 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0V8IRQ4
Locus tag QNH15_RS01245 Protein ID WP_061975875.1
Coordinates 218042..218323 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH15_RS01220 (QNH15_01220) 213565..214320 + 756 WP_283891976.1 STAS domain-containing protein -
QNH15_RS01225 (QNH15_01225) 214363..214959 - 597 WP_283891978.1 rhomboid family intramembrane serine protease -
QNH15_RS01230 (QNH15_01230) 215046..215402 + 357 WP_283891979.1 holo-ACP synthase -
QNH15_RS01235 (QNH15_01235) 215546..216580 + 1035 WP_283891980.1 outer membrane lipoprotein carrier protein LolA -
QNH15_RS01240 (QNH15_01240) 216710..217897 + 1188 WP_283891982.1 alanine racemase -
QNH15_RS01245 (QNH15_01245) 218042..218323 + 282 WP_061975875.1 ribbon-helix-helix protein, CopG family Antitoxin
QNH15_RS01250 (QNH15_01250) 218328..218678 + 351 WP_007200228.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QNH15_RS01255 (QNH15_01255) 218849..219664 + 816 WP_283891987.1 STAS domain-containing protein -
QNH15_RS01260 (QNH15_01260) 219677..220033 + 357 WP_061975879.1 STAS domain-containing protein -
QNH15_RS01265 (QNH15_01265) 220036..220437 + 402 WP_129478414.1 anti-sigma regulatory factor -
QNH15_RS01270 (QNH15_01270) 220448..221455 + 1008 WP_283891992.1 PP2C family protein-serine/threonine phosphatase -
QNH15_RS01275 (QNH15_01275) 221517..221849 + 333 WP_283891994.1 STAS domain-containing protein -
QNH15_RS01280 (QNH15_01280) 221846..222331 + 486 WP_283891995.1 anti-sigma B factor RsbW -
QNH15_RS01285 (QNH15_01285) 222297..223088 + 792 WP_283891997.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13060.17 Da        Isoelectric Point: 6.4714

>T282638 WP_007200228.1 NZ_CP126109:218328-218678 [Fictibacillus enclensis]
MIVKRGDVYFADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMRRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10916.65 Da        Isoelectric Point: 7.2048

>AT282638 WP_061975875.1 NZ_CP126109:218042-218323 [Fictibacillus enclensis]
VSELANTKRIVISLPQQIINEIDRMIKNENLDRSEFIHQATKMYIREKKKRHIRESMRQGYMEMAKINLNIASEAFLLEE
EAEITVDRLVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V8IRG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0V8IRQ4

References