Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 254011..254647 Replicon chromosome
Accession NZ_CP126108
Organism Cytobacillus firmus strain SQ11

Toxin (Protein)


Gene name mazF Uniprot ID W7KPR3
Locus tag QNH42_RS01385 Protein ID WP_009336311.1
Coordinates 254297..254647 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID W7L1R3
Locus tag QNH42_RS01380 Protein ID WP_035331931.1
Coordinates 254011..254292 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH42_RS01360 (QNH42_01360) 249562..250287 - 726 WP_163144744.1 rhomboid family intramembrane serine protease -
QNH42_RS01365 (QNH42_01365) 250443..250796 + 354 WP_048008767.1 holo-ACP synthase -
QNH42_RS01370 (QNH42_01370) 250941..251954 + 1014 WP_283935291.1 outer membrane lipoprotein carrier protein LolA -
QNH42_RS01375 (QNH42_01375) 252389..253543 + 1155 WP_226620280.1 alanine racemase -
QNH42_RS01380 (QNH42_01380) 254011..254292 + 282 WP_035331931.1 YlcI/YnfO family protein Antitoxin
QNH42_RS01385 (QNH42_01385) 254297..254647 + 351 WP_009336311.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QNH42_RS01390 (QNH42_01390) 255021..255854 + 834 WP_163144748.1 RsbT co-antagonist protein RsbRA -
QNH42_RS01395 (QNH42_01395) 255851..256213 + 363 WP_009336309.1 STAS domain-containing protein -
QNH42_RS01400 (QNH42_01400) 256218..256619 + 402 WP_048008772.1 anti-sigma regulatory factor -
QNH42_RS01405 (QNH42_01405) 256631..257641 + 1011 WP_048008773.1 PP2C family protein-serine/threonine phosphatase -
QNH42_RS01410 (QNH42_01410) 257702..258034 + 333 WP_035331808.1 anti-sigma factor antagonist -
QNH42_RS01415 (QNH42_01415) 258031..258504 + 474 WP_009336304.1 anti-sigma B factor RsbW -
QNH42_RS01420 (QNH42_01420) 258482..259276 + 795 WP_048008774.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 4.8998

>T282636 WP_009336311.1 NZ_CP126108:254297-254647 [Cytobacillus firmus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEAVQISLGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10831.33 Da        Isoelectric Point: 7.2028

>AT282636 WP_035331931.1 NZ_CP126108:254011-254292 [Cytobacillus firmus]
VSESSTTTEIMVKLPQHLLTELDGFAKQENVNRSEFIYQATKMYLRERKKRQIRESMRRGYMEMAKINLTIASEAFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A169FD46

Antitoxin

Source ID Structure
AlphaFold DB W7L1R3

References