Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 232037..232673 Replicon chromosome
Accession NZ_CP126107
Organism Neobacillus sp. SuZ13

Toxin (Protein)


Gene name mazF Uniprot ID K6DRS5
Locus tag QNH17_RS01225 Protein ID WP_007083556.1
Coordinates 232323..232673 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID K6CIS6
Locus tag QNH17_RS01220 Protein ID WP_007083557.1
Coordinates 232037..232318 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH17_RS01200 (QNH17_01200) 227919..228647 - 729 WP_283877028.1 rhomboid family intramembrane serine protease -
QNH17_RS01205 (QNH17_01205) 228748..229098 + 351 WP_283877029.1 holo-ACP synthase -
QNH17_RS01210 (QNH17_01210) 229465..230478 + 1014 WP_283877030.1 outer membrane lipoprotein carrier protein LolA -
QNH17_RS01215 (QNH17_01215) 230602..231765 + 1164 WP_283877032.1 alanine racemase -
QNH17_RS01220 (QNH17_01220) 232037..232318 + 282 WP_007083557.1 CopG family ribbon-helix-helix protein Antitoxin
QNH17_RS01225 (QNH17_01225) 232323..232673 + 351 WP_007083556.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QNH17_RS01230 (QNH17_01230) 233047..235221 + 2175 WP_283877034.1 Tex family protein -
QNH17_RS01235 (QNH17_01235) 235666..235779 - 114 WP_088085061.1 cortex morphogenetic protein CmpA -
QNH17_RS01240 (QNH17_01240) 235868..236341 + 474 WP_283877035.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 4.8998

>T282635 WP_007083556.1 NZ_CP126107:232323-232673 [Neobacillus sp. SuZ13]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10722.27 Da        Isoelectric Point: 7.2028

>AT282635 WP_007083557.1 NZ_CP126107:232037-232318 [Neobacillus sp. SuZ13]
VSESGATTEILVKLPQHLLTELDGFVKQENVNRSEFIYQATKMYLRERKKRQIRESMRRGYMEMAKINLGIASEAFLAEY
EAEHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K6DRS5

Antitoxin

Source ID Structure
AlphaFold DB K6CIS6

References