Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 282137..282776 Replicon chromosome
Accession NZ_CP126106
Organism Peribacillus simplex strain RZ14

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag QNH43_RS01460 Protein ID WP_034306610.1
Coordinates 282426..282776 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag QNH43_RS01455 Protein ID WP_034306380.1
Coordinates 282137..282418 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH43_RS01435 (QNH43_01435) 278272..278862 - 591 WP_076373136.1 rhomboid family intramembrane serine protease -
QNH43_RS01440 (QNH43_01440) 278971..279321 + 351 WP_053537119.1 holo-ACP synthase -
QNH43_RS01445 (QNH43_01445) 279566..280570 + 1005 WP_076373138.1 outer membrane lipoprotein carrier protein LolA -
QNH43_RS01450 (QNH43_01450) 280792..281976 + 1185 WP_283916559.1 alanine racemase -
QNH43_RS01455 (QNH43_01455) 282137..282418 + 282 WP_034306380.1 antitoxin EndoAI Antitoxin
QNH43_RS01460 (QNH43_01460) 282426..282776 + 351 WP_034306610.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QNH43_RS01465 (QNH43_01465) 283190..284017 + 828 WP_283916560.1 RsbT co-antagonist protein RsbRA -
QNH43_RS01470 (QNH43_01470) 284020..284376 + 357 WP_283916561.1 STAS domain-containing protein -
QNH43_RS01475 (QNH43_01475) 284380..284781 + 402 WP_048682056.1 anti-sigma regulatory factor -
QNH43_RS01480 (QNH43_01480) 284791..285801 + 1011 WP_283916562.1 PP2C family protein-serine/threonine phosphatase -
QNH43_RS01485 (QNH43_01485) 285861..286193 + 333 WP_098372176.1 anti-sigma factor antagonist -
QNH43_RS01490 (QNH43_01490) 286190..286663 + 474 WP_076373148.1 anti-sigma B factor RsbW -
QNH43_RS01495 (QNH43_01495) 286641..287429 + 789 WP_034306363.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12955.06 Da        Isoelectric Point: 7.2029

>T282634 WP_034306610.1 NZ_CP126106:282426-282776 [Peribacillus simplex]
IVVKRGDVYFADLSPVVGSEQGGTRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEPMMQKVNEALQISLGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10713.13 Da        Isoelectric Point: 5.9054

>AT282634 WP_034306380.1 NZ_CP126106:282137-282418 [Peribacillus simplex]
VSESSATREILIRLPQNFLTELDGYASEENVNRSEFIYRATKMYLRERKKKEFRESMKRGYIEMAAINLTIASEAFQAEF
EAGHCVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References