282633

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1240999..1241916 Replicon chromosome
Accession NZ_CP126105
Organism Bacillus velezensis strain NJ26

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag QNH27_RS06485 Protein ID WP_007407256.1
Coordinates 1241170..1241916 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag QNH27_RS06480 Protein ID WP_003154807.1
Coordinates 1240999..1241169 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH27_RS06440 (QNH27_06440) 1236232..1237854 + 1623 WP_032874601.1 pyocin knob domain-containing protein -
QNH27_RS06445 (QNH27_06445) 1237867..1238238 + 372 WP_032874603.1 XkdW family protein -
QNH27_RS06450 (QNH27_06450) 1238243..1238440 + 198 WP_032874605.1 XkdX family protein -
QNH27_RS06455 (QNH27_06455) 1238497..1239258 + 762 WP_032874607.1 hypothetical protein -
QNH27_RS06460 (QNH27_06460) 1239310..1239573 + 264 WP_003154815.1 hemolysin XhlA family protein -
QNH27_RS06465 (QNH27_06465) 1239587..1239850 + 264 WP_003154813.1 phage holin -
QNH27_RS06470 (QNH27_06470) 1239864..1240742 + 879 WP_032874609.1 N-acetylmuramoyl-L-alanine amidase -
QNH27_RS06475 (QNH27_06475) 1240777..1240902 - 126 WP_003154809.1 hypothetical protein -
QNH27_RS06480 (QNH27_06480) 1240999..1241169 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
QNH27_RS06485 (QNH27_06485) 1241170..1241916 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
QNH27_RS06490 (QNH27_06490) 1242021..1243019 - 999 WP_032874611.1 inorganic phosphate transporter -
QNH27_RS06495 (QNH27_06495) 1243032..1243649 - 618 WP_032874614.1 DUF47 domain-containing protein -
QNH27_RS06500 (QNH27_06500) 1243935..1245251 - 1317 WP_032874616.1 amino acid permease -
QNH27_RS06505 (QNH27_06505) 1245573..1246523 + 951 WP_032874618.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T282633 WP_007407256.1 NZ_CP126105:c1241916-1241170 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT282633 WP_003154807.1 NZ_CP126105:c1241169-1240999 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References