282630

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 479716..480353 Replicon chromosome
Accession NZ_CP126104
Organism Bacillus velezensis strain MB7_B11

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag QNH19_RS02450 Protein ID WP_003156187.1
Coordinates 480003..480353 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID I2HMS5
Locus tag QNH19_RS02445 Protein ID WP_003156188.1
Coordinates 479716..479997 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH19_RS02425 (QNH19_02425) 476081..476680 - 600 WP_003156193.1 rhomboid family intramembrane serine protease -
QNH19_RS02430 (QNH19_02430) 476773..477138 + 366 WP_007410229.1 holo-ACP synthase -
QNH19_RS02435 (QNH19_02435) 477303..478310 + 1008 WP_007410230.1 outer membrane lipoprotein carrier protein LolA -
QNH19_RS02440 (QNH19_02440) 478427..479596 + 1170 WP_025284272.1 alanine racemase -
QNH19_RS02445 (QNH19_02445) 479716..479997 + 282 WP_003156188.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
QNH19_RS02450 (QNH19_02450) 480003..480353 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QNH19_RS02455 (QNH19_02455) 480471..481292 + 822 WP_003156182.1 STAS domain-containing protein -
QNH19_RS02460 (QNH19_02460) 481297..481662 + 366 WP_003156180.1 RsbT antagonist protein RsbS -
QNH19_RS02465 (QNH19_02465) 481665..482066 + 402 WP_003156178.1 anti-sigma regulatory factor -
QNH19_RS02470 (QNH19_02470) 482078..483085 + 1008 WP_007410233.1 PP2C family protein-serine/threonine phosphatase -
QNH19_RS02475 (QNH19_02475) 483149..483478 + 330 WP_003156176.1 anti-sigma factor antagonist RsbV -
QNH19_RS02480 (QNH19_02480) 483475..483957 + 483 WP_007609591.1 anti-sigma B factor RsbW -
QNH19_RS02485 (QNH19_02485) 483923..484711 + 789 WP_003156171.1 RNA polymerase sigma factor SigB -
QNH19_RS02490 (QNH19_02490) 484711..485313 + 603 WP_283887783.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T282630 WP_003156187.1 NZ_CP126104:480003-480353 [Bacillus velezensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10562.92 Da        Isoelectric Point: 6.4706

>AT282630 WP_003156188.1 NZ_CP126104:479716-479997 [Bacillus velezensis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8

Antitoxin

Source ID Structure
AlphaFold DB I2HMS5

References