Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 256537..257173 Replicon chromosome
Accession NZ_CP126102
Organism Cytobacillus firmus strain LN5

Toxin (Protein)


Gene name mazF Uniprot ID W7KPR3
Locus tag QNH44_RS01400 Protein ID WP_009336311.1
Coordinates 256823..257173 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID W7L1R3
Locus tag QNH44_RS01395 Protein ID WP_035331931.1
Coordinates 256537..256818 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH44_RS01375 (QNH44_01375) 252165..252890 - 726 WP_163144744.1 rhomboid family intramembrane serine protease -
QNH44_RS01380 (QNH44_01380) 253046..253399 + 354 WP_163144745.1 holo-ACP synthase -
QNH44_RS01385 (QNH44_01385) 253542..254555 + 1014 WP_262177012.1 outer membrane lipoprotein carrier protein LolA -
QNH44_RS01390 (QNH44_01390) 255198..256352 + 1155 WP_258752060.1 alanine racemase -
QNH44_RS01395 (QNH44_01395) 256537..256818 + 282 WP_035331931.1 YlcI/YnfO family protein Antitoxin
QNH44_RS01400 (QNH44_01400) 256823..257173 + 351 WP_009336311.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QNH44_RS01405 (QNH44_01405) 257547..258380 + 834 WP_048008771.1 RsbT co-antagonist protein RsbRA -
QNH44_RS01410 (QNH44_01410) 258377..258739 + 363 WP_009336309.1 STAS domain-containing protein -
QNH44_RS01415 (QNH44_01415) 258744..259145 + 402 WP_048008772.1 anti-sigma regulatory factor -
QNH44_RS01420 (QNH44_01420) 259157..260167 + 1011 WP_048008773.1 PP2C family protein-serine/threonine phosphatase -
QNH44_RS01425 (QNH44_01425) 260228..260560 + 333 WP_035331808.1 anti-sigma factor antagonist -
QNH44_RS01430 (QNH44_01430) 260557..261030 + 474 WP_009336304.1 anti-sigma B factor RsbW -
QNH44_RS01435 (QNH44_01435) 261008..261802 + 795 WP_048008774.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 4.8998

>T282629 WP_009336311.1 NZ_CP126102:256823-257173 [Cytobacillus firmus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEAVQISLGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10831.33 Da        Isoelectric Point: 7.2028

>AT282629 WP_035331931.1 NZ_CP126102:256537-256818 [Cytobacillus firmus]
VSESSTTTEIMVKLPQHLLTELDGFAKQENVNRSEFIYQATKMYLRERKKRQIRESMRRGYMEMAKINLTIASEAFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A169FD46

Antitoxin

Source ID Structure
AlphaFold DB W7L1R3

References