Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 256537..257173 Replicon chromosome
Accession NZ_CP126102
Organism Cytobacillus firmus strain LN5

Toxin (Protein)


Gene name mazF Uniprot ID W7KPR3
Locus tag QNH44_RS01400 Protein ID WP_009336311.1
Coordinates 256823..257173 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID W7L1R3
Locus tag QNH44_RS01395 Protein ID WP_035331931.1
Coordinates 256537..256818 (+) Length 94 a.a.

Genomic Context

QNH44_RS01380QNH44_RS01385QNH44_RS01390QNH44_RS01395QNH44_RS01400QNH44_RS01405QNH44_RS01410QNH44_RS01415QNH44_RS01420QNH44_RS01425QNH44_RS01430QNH44_RS01435QNH44_RS01375
Location: 253046..253399 (354 bp)
Type: Others
Protein ID: WP_163144745.1
Location: 253542..254555 (1014 bp)
Type: Others
Protein ID: WP_262177012.1
Location: 255198..256352 (1155 bp)
Type: Others
Protein ID: WP_258752060.1
Location: 256537..256818 (282 bp)
Type: Antitoxin
Protein ID: WP_035331931.1
Location: 256823..257173 (351 bp)
Type: Toxin
Protein ID: WP_009336311.1
Location: 257547..258380 (834 bp)
Type: Others
Protein ID: WP_048008771.1
Location: 258377..258739 (363 bp)
Type: Others
Protein ID: WP_009336309.1
Location: 258744..259145 (402 bp)
Type: Others
Protein ID: WP_048008772.1
Location: 259157..260167 (1011 bp)
Type: Others
Protein ID: WP_048008773.1
Location: 260228..260560 (333 bp)
Type: Others
Protein ID: WP_035331808.1
Location: 260557..261030 (474 bp)
Type: Others
Protein ID: WP_009336304.1
Location: 261008..261802 (795 bp)
Type: Others
Protein ID: WP_048008774.1
Location: 252165..252890 (726 bp)
Type: Others
Protein ID: WP_163144744.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QNH44_RS01375 (QNH44_01375)252165..252890-726WP_163144744.1rhomboid family intramembrane serine protease-
QNH44_RS01380 (QNH44_01380)253046..253399+354WP_163144745.1holo-ACP synthase-
QNH44_RS01385 (QNH44_01385)253542..254555+1014WP_262177012.1outer membrane lipoprotein carrier protein LolA-
QNH44_RS01390 (QNH44_01390)255198..256352+1155WP_258752060.1alanine racemase-
QNH44_RS01395 (QNH44_01395)256537..256818+282WP_035331931.1YlcI/YnfO family proteinAntitoxin
QNH44_RS01400 (QNH44_01400)256823..257173+351WP_009336311.1type II toxin-antitoxin system endoribonuclease NdoAToxin
QNH44_RS01405 (QNH44_01405)257547..258380+834WP_048008771.1RsbT co-antagonist protein RsbRA-
QNH44_RS01410 (QNH44_01410)258377..258739+363WP_009336309.1STAS domain-containing protein-
QNH44_RS01415 (QNH44_01415)258744..259145+402WP_048008772.1anti-sigma regulatory factor-
QNH44_RS01420 (QNH44_01420)259157..260167+1011WP_048008773.1PP2C family protein-serine/threonine phosphatase-
QNH44_RS01425 (QNH44_01425)260228..260560+333WP_035331808.1anti-sigma factor antagonist-
QNH44_RS01430 (QNH44_01430)260557..261030+474WP_009336304.1anti-sigma B factor RsbW-
QNH44_RS01435 (QNH44_01435)261008..261802+795WP_048008774.1RNA polymerase sigma factor SigB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 4.8998

>T282629 WP_009336311.1 NZ_CP126102:256823-257173 [Cytobacillus firmus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEAVQISLGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10831.33 Da        Isoelectric Point: 7.2028

>AT282629 WP_035331931.1 NZ_CP126102:256537-256818 [Cytobacillus firmus]
VSESSTTTEIMVKLPQHLLTELDGFAKQENVNRSEFIYQATKMYLRERKKRQIRESMRRGYMEMAKINLTIASEAFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A169FD46

Antitoxin

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Source
ID
Structure
AlphaFold DBW7L1R3

References