Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1136667..1137165 Replicon chromosome
Accession NC_018630
Organism Streptococcus pneumoniae gamPNI0373

Toxin (Protein)


Gene name relE Uniprot ID C1CEI0
Locus tag HMPREF1038_RS06035 Protein ID WP_001823540.1
Coordinates 1136667..1136921 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag HMPREF1038_RS06040 Protein ID WP_000208080.1
Coordinates 1136923..1137165 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF1038_RS06020 (HMPREF1038_01223) 1131936..1134404 - 2469 WP_001152988.1 DNA gyrase subunit A -
HMPREF1038_RS06025 (HMPREF1038_01224) 1134598..1135584 + 987 WP_000204727.1 L-lactate dehydrogenase -
HMPREF1038_RS06030 (HMPREF1038_01225) 1135847..1136620 - 774 WP_025172523.1 ion transporter -
HMPREF1038_RS06035 (HMPREF1038_01226) 1136667..1136921 - 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HMPREF1038_RS06040 (HMPREF1038_01227) 1136923..1137165 - 243 WP_000208080.1 hypothetical protein Antitoxin
HMPREF1038_RS06045 (HMPREF1038_01228) 1137256..1138065 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
HMPREF1038_RS06050 (HMPREF1038_01229) 1138067..1139416 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
HMPREF1038_RS06055 (HMPREF1038_01230) 1139409..1140113 - 705 WP_000722076.1 response regulator transcription factor -
HMPREF1038_RS06060 (HMPREF1038_01231) 1140168..1141343 - 1176 WP_000886147.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10040.76 Da        Isoelectric Point: 10.9371

>T28262 WP_001823540.1 NC_018630:c1136921-1136667 [Streptococcus pneumoniae gamPNI0373]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T28262 NC_018630:c1136921-1136667 [Streptococcus pneumoniae gamPNI0373]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGCCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT28262 WP_000208080.1 NC_018630:c1137165-1136923 [Streptococcus pneumoniae gamPNI0373]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT28262 NC_018630:c1137165-1136923 [Streptococcus pneumoniae gamPNI0373]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C1CEI0

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References