282619

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1371268..1372184 Replicon chromosome
Accession NZ_CP126100
Organism Bacillus halotolerans strain LN2

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A7G7U9Y2
Locus tag QNH41_RS07095 Protein ID WP_024121091.1
Coordinates 1371438..1372184 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A7G7U9Y3
Locus tag QNH41_RS07090 Protein ID WP_024121090.1
Coordinates 1371268..1371438 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH41_RS07055 (1368131) 1368131..1368460 + 330 WP_283912936.1 XkdW family protein -
QNH41_RS07060 (1368457) 1368457..1368621 + 165 WP_185848046.1 XkdX family protein -
QNH41_RS07065 (1368665) 1368665..1369504 + 840 WP_283912937.1 phage portal protein -
QNH41_RS07070 (1369560) 1369560..1369829 + 270 WP_024121085.1 hemolysin XhlA family protein -
QNH41_RS07075 (1369841) 1369841..1370104 + 264 WP_024121086.1 phage holin -
QNH41_RS07080 (1370117) 1370117..1371010 + 894 WP_283912938.1 N-acetylmuramoyl-L-alanine amidase -
QNH41_RS07085 (1371047) 1371047..1371184 - 138 WP_125825426.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
QNH41_RS07090 (1371268) 1371268..1371438 - 171 WP_024121090.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
QNH41_RS07095 (1371438) 1371438..1372184 - 747 WP_024121091.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
QNH41_RS07100 (1372293) 1372293..1373294 - 1002 WP_024121092.1 inorganic phosphate transporter -
QNH41_RS07105 (1373307) 1373307..1373924 - 618 WP_010333926.1 DUF47 domain-containing protein -
QNH41_RS07110 (1374201) 1374201..1375517 - 1317 WP_099042852.1 serine/threonine exchanger -
QNH41_RS07115 (1375912) 1375912..1376862 + 951 WP_127695396.1 ring-cleaving dioxygenase -
QNH41_RS07120 (1377022) 1377022..1377102 + 81 Protein_1339 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1336547..1380625 44078


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29076.48 Da        Isoelectric Point: 4.4986

>T282619 WP_024121091.1 NZ_CP126100:c1372184-1371438 [Bacillus halotolerans]
MLLFFQIMVWCTMAALGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMIYWTYDPSSLFTNWERYVIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLDRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CHYSTQSDKDRLTEHMEDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6578.62 Da        Isoelectric Point: 10.9236

>AT282619 WP_024121090.1 NZ_CP126100:c1371438-1371268 [Bacillus halotolerans]
MENAFQNGCHPRAKKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G7U9Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7U9Y3

References