Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 520938..521574 Replicon chromosome
Accession NZ_CP126100
Organism Bacillus halotolerans strain LN2

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag QNH41_RS02650 Protein ID WP_003156187.1
Coordinates 521224..521574 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G4NU32
Locus tag QNH41_RS02645 Protein ID WP_003225183.1
Coordinates 520938..521219 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH41_RS02625 (517293) 517293..517892 - 600 WP_024120294.1 rhomboid family intramembrane serine protease -
QNH41_RS02630 (517987) 517987..518352 + 366 WP_106020948.1 holo-ACP synthase -
QNH41_RS02635 (518518) 518518..519534 + 1017 WP_081638241.1 outer membrane lipoprotein carrier protein LolA -
QNH41_RS02640 (519651) 519651..520820 + 1170 WP_024120297.1 alanine racemase -
QNH41_RS02645 (520938) 520938..521219 + 282 WP_003225183.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
QNH41_RS02650 (521224) 521224..521574 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QNH41_RS02655 (521690) 521690..522514 + 825 WP_283912799.1 RsbT co-antagonist protein RsbRA -
QNH41_RS02660 (522519) 522519..522884 + 366 WP_003225190.1 RsbT antagonist protein RsbS -
QNH41_RS02665 (522887) 522887..523288 + 402 WP_106020946.1 serine/threonine-protein kinase RsbT -
QNH41_RS02670 (523300) 523300..524307 + 1008 WP_024120300.1 phosphoserine phosphatase RsbU -
QNH41_RS02675 (524368) 524368..524697 + 330 WP_024120301.1 anti-sigma factor antagonist RsbV -
QNH41_RS02680 (524694) 524694..525176 + 483 WP_024120302.1 anti-sigma B factor RsbW -
QNH41_RS02685 (525142) 525142..525930 + 789 WP_024120303.1 RNA polymerase sigma factor SigB -
QNH41_RS02690 (525930) 525930..526529 + 600 WP_024120304.1 phosphoserine phosphatase RsbX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T282618 WP_003156187.1 NZ_CP126100:521224-521574 [Bacillus halotolerans]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10546.92 Da        Isoelectric Point: 6.4708

>AT282618 WP_003225183.1 NZ_CP126100:520938-521219 [Bacillus halotolerans]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8

Antitoxin

Source ID Structure
PDB 4ME7
AlphaFold DB G4NU32

References