Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 239794..240436 Replicon chromosome
Accession NZ_CP126099
Organism Bacillus wiedmannii strain LN15

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag QNH45_RS01345 Protein ID WP_000635963.1
Coordinates 240086..240436 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag QNH45_RS01340 Protein ID WP_000004570.1
Coordinates 239794..240081 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH45_RS01315 (QNH45_01315) 235007..235969 + 963 WP_283883842.1 UV DNA damage repair endonuclease UvsE -
QNH45_RS01320 (QNH45_01320) 236089..236637 - 549 WP_283883844.1 rhomboid family intramembrane serine protease -
QNH45_RS01325 (QNH45_01325) 236730..237089 + 360 WP_283883846.1 holo-ACP synthase -
QNH45_RS01330 (QNH45_01330) 237246..238196 + 951 WP_283886254.1 outer membrane lipoprotein carrier protein LolA -
QNH45_RS01335 (QNH45_01335) 238315..239484 + 1170 WP_283883848.1 alanine racemase -
QNH45_RS01340 (QNH45_01340) 239794..240081 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
QNH45_RS01345 (QNH45_01345) 240086..240436 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QNH45_RS01350 (QNH45_01350) 240505..242673 + 2169 WP_000426248.1 Tex family protein -
QNH45_RS01355 (QNH45_01355) 242731..242847 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
QNH45_RS01360 (QNH45_01360) 243037..243501 + 465 WP_283883850.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T282616 WP_000635963.1 NZ_CP126099:240086-240436 [Bacillus wiedmannii]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT282616 WP_000004570.1 NZ_CP126099:239794-240081 [Bacillus wiedmannii]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References