Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 280888..281527 Replicon chromosome
Accession NZ_CP126098
Organism Peribacillus frigoritolerans strain LC22

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag QNH16_RS01445 Protein ID WP_034306610.1
Coordinates 281177..281527 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag QNH16_RS01440 Protein ID WP_034306380.1
Coordinates 280888..281169 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH16_RS01420 (QNH16_01420) 277026..277616 - 591 WP_063592372.1 rhomboid family intramembrane serine protease -
QNH16_RS01425 (QNH16_01425) 277724..278074 + 351 WP_063592371.1 holo-ACP synthase -
QNH16_RS01430 (QNH16_01430) 278317..279321 + 1005 WP_063592370.1 outer membrane lipoprotein carrier protein LolA -
QNH16_RS01435 (QNH16_01435) 279540..280727 + 1188 WP_283866941.1 alanine racemase -
QNH16_RS01440 (QNH16_01440) 280888..281169 + 282 WP_034306380.1 antitoxin EndoAI Antitoxin
QNH16_RS01445 (QNH16_01445) 281177..281527 + 351 WP_034306610.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QNH16_RS01450 (QNH16_01450) 281941..282768 + 828 WP_048682050.1 RsbT co-antagonist protein RsbRA -
QNH16_RS01455 (QNH16_01455) 282771..283127 + 357 WP_048682053.1 STAS domain-containing protein -
QNH16_RS01460 (QNH16_01460) 283131..283532 + 402 WP_048682056.1 anti-sigma regulatory factor -
QNH16_RS01465 (QNH16_01465) 283542..284552 + 1011 WP_063592368.1 PP2C family protein-serine/threonine phosphatase -
QNH16_RS01470 (QNH16_01470) 284612..284944 + 333 WP_034306369.1 anti-sigma factor antagonist -
QNH16_RS01475 (QNH16_01475) 284941..285414 + 474 WP_034306366.1 anti-sigma B factor RsbW -
QNH16_RS01480 (QNH16_01480) 285392..286180 + 789 WP_034306363.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12955.06 Da        Isoelectric Point: 7.2029

>T282615 WP_034306610.1 NZ_CP126098:281177-281527 [Peribacillus frigoritolerans]
IVVKRGDVYFADLSPVVGSEQGGTRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEPMMQKVNEALQISLGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10713.13 Da        Isoelectric Point: 5.9054

>AT282615 WP_034306380.1 NZ_CP126098:280888-281169 [Peribacillus frigoritolerans]
VSESSATREILIRLPQNFLTELDGYASEENVNRSEFIYRATKMYLRERKKKEFRESMKRGYIEMAAINLTIASEAFQAEF
EAGHCVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References