Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1320178..1321094 Replicon chromosome
Accession NZ_CP126097
Organism Bacillus subtilis strain KF24

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag QNK06_RS07015 Protein ID WP_220396471.1
Coordinates 1320348..1321094 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag QNK06_RS07010 Protein ID WP_003232646.1
Coordinates 1320178..1320348 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNK06_RS06970 (1315892) 1315892..1316221 + 330 WP_283934290.1 XkdW family protein -
QNK06_RS06975 (1316218) 1316218..1316382 + 165 WP_181217004.1 XkdX family protein -
QNK06_RS06980 (1316429) 1316429..1317268 + 840 WP_283934291.1 phage-like element PBSX protein XepA -
QNK06_RS06985 (1317321) 1317321..1317590 + 270 WP_015252265.1 hemolysin XhlA family protein -
QNK06_RS06990 (1317603) 1317603..1317866 + 264 WP_014479566.1 phage holin -
QNK06_RS06995 (1317879) 1317879..1318775 + 897 WP_181217006.1 N-acetylmuramoyl-L-alanine amidase -
QNK06_RS07000 (1318852) 1318852..1319943 + 1092 WP_181217007.1 acyltransferase family protein -
QNK06_RS07005 (1319940) 1319940..1320092 - 153 WP_131228329.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
QNK06_RS07010 (1320178) 1320178..1320348 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
QNK06_RS07015 (1320348) 1320348..1321094 - 747 WP_220396471.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
QNK06_RS07020 (1321204) 1321204..1322205 - 1002 WP_003232642.1 inorganic phosphate transporter -
QNK06_RS07025 (1322218) 1322218..1322835 - 618 WP_003218470.1 DUF47 domain-containing protein -
QNK06_RS07030 (1323111) 1323111..1324427 - 1317 WP_085186195.1 serine/threonine exchanger -
QNK06_RS07035 (1324816) 1324816..1325766 + 951 WP_015252261.1 ring-cleaving dioxygenase -
QNK06_RS07040 (1325875) 1325875..1325970 + 96 Protein_1326 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29003.46 Da        Isoelectric Point: 4.6878

>T282608 WP_220396471.1 NZ_CP126097:c1321094-1320348 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDGPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT282608 WP_003232646.1 NZ_CP126097:c1320348-1320178 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References