Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 509240..509876 Replicon chromosome
Accession NZ_CP126097
Organism Bacillus subtilis strain KF24

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag QNK06_RS02610 Protein ID WP_003156187.1
Coordinates 509526..509876 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G4NU32
Locus tag QNK06_RS02605 Protein ID WP_003225183.1
Coordinates 509240..509521 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNK06_RS02585 (505599) 505599..506198 - 600 WP_219144775.1 rhomboid family intramembrane serine protease -
QNK06_RS02590 (506293) 506293..506658 + 366 WP_015252768.1 holo-ACP synthase -
QNK06_RS02595 (506824) 506824..507840 + 1017 WP_003234282.1 outer membrane lipoprotein carrier protein LolA -
QNK06_RS02600 (507955) 507955..509124 + 1170 WP_219144776.1 alanine racemase -
QNK06_RS02605 (509240) 509240..509521 + 282 WP_003225183.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
QNK06_RS02610 (509526) 509526..509876 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QNK06_RS02615 (509992) 509992..510816 + 825 WP_009966610.1 RsbT co-antagonist protein RsbRA -
QNK06_RS02620 (510821) 510821..511186 + 366 WP_003225190.1 RsbT antagonist protein RsbS -
QNK06_RS02625 (511190) 511190..511591 + 402 WP_003225192.1 serine/threonine-protein kinase RsbT -
QNK06_RS02630 (511603) 511603..512610 + 1008 WP_014478900.1 phosphoserine phosphatase RsbU -
QNK06_RS02635 (512679) 512679..513008 + 330 WP_014475877.1 anti-sigma factor antagonist RsbV -
QNK06_RS02640 (513005) 513005..513487 + 483 WP_283934068.1 anti-sigma B factor RsbW -
QNK06_RS02645 (513453) 513453..514241 + 789 WP_003246715.1 RNA polymerase sigma factor SigB -
QNK06_RS02650 (514241) 514241..514840 + 600 WP_003246608.1 phosphoserine phosphatase RsbX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T282607 WP_003156187.1 NZ_CP126097:509526-509876 [Bacillus subtilis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10546.92 Da        Isoelectric Point: 6.4708

>AT282607 WP_003225183.1 NZ_CP126097:509240-509521 [Bacillus subtilis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8

Antitoxin

Source ID Structure
PDB 4ME7
AlphaFold DB G4NU32

References