Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 547878..548514 Replicon chromosome
Accession NZ_CP126096
Organism Bacillus altitudinis strain G6S2

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag QNH34_RS02630 Protein ID WP_003214169.1
Coordinates 548164..548514 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag QNH34_RS02625 Protein ID WP_003214273.1
Coordinates 547878..548159 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH34_RS02605 (QNH34_02605) 544024..544629 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
QNH34_RS02610 (QNH34_02610) 544724..545089 + 366 WP_283933323.1 holo-ACP synthase -
QNH34_RS02615 (QNH34_02615) 545250..546266 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
QNH34_RS02620 (QNH34_02620) 546402..547583 + 1182 WP_061418044.1 alanine racemase -
QNH34_RS02625 (QNH34_02625) 547878..548159 + 282 WP_003214273.1 hypothetical protein Antitoxin
QNH34_RS02630 (QNH34_02630) 548164..548514 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QNH34_RS02635 (QNH34_02635) 548629..549459 + 831 WP_017358395.1 RsbT co-antagonist protein RsbRA -
QNH34_RS02640 (QNH34_02640) 549464..549832 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
QNH34_RS02645 (QNH34_02645) 549835..550236 + 402 WP_003214085.1 anti-sigma regulatory factor -
QNH34_RS02650 (QNH34_02650) 550247..551254 + 1008 WP_017358394.1 PP2C family protein-serine/threonine phosphatase -
QNH34_RS02655 (QNH34_02655) 551314..551643 + 330 WP_017358393.1 anti-sigma factor antagonist -
QNH34_RS02660 (QNH34_02660) 551640..552128 + 489 WP_178929502.1 anti-sigma B factor RsbW -
QNH34_RS02665 (QNH34_02665) 552094..552882 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
QNH34_RS02670 (QNH34_02670) 552882..553481 + 600 WP_024719202.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T282606 WP_003214169.1 NZ_CP126096:548164-548514 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT282606 WP_003214273.1 NZ_CP126096:547878-548159 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References