Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1285312..1285947 Replicon chromosome
Accession NZ_CP126095
Organism Paenibacillus sp. G2S3

Toxin (Protein)


Gene name mazF Uniprot ID A0A0W1B4L6
Locus tag QNH28_RS05655 Protein ID WP_042124727.1
Coordinates 1285597..1285947 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A089IDM2
Locus tag QNH28_RS05650 Protein ID WP_025698676.1
Coordinates 1285312..1285593 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH28_RS05630 (QNH28_05630) 1280755..1282146 + 1392 WP_283910529.1 helix-turn-helix transcriptional regulator -
QNH28_RS05635 (QNH28_05635) 1282233..1282406 + 174 WP_283910530.1 aspartyl-phosphate phosphatase Spo0E family protein -
QNH28_RS05640 (QNH28_05640) 1282641..1283726 + 1086 WP_094872533.1 outer membrane lipoprotein carrier protein LolA -
QNH28_RS05645 (QNH28_05645) 1283916..1285097 + 1182 WP_283910531.1 alanine racemase -
QNH28_RS05650 (QNH28_05650) 1285312..1285593 + 282 WP_025698676.1 CopG family ribbon-helix-helix protein Antitoxin
QNH28_RS05655 (QNH28_05655) 1285597..1285947 + 351 WP_042124727.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QNH28_RS05660 (QNH28_05660) 1286104..1286712 + 609 WP_283910532.1 TetR/AcrR family transcriptional regulator -
QNH28_RS05665 (QNH28_05665) 1286893..1288092 + 1200 WP_283910533.1 MFS transporter -
QNH28_RS05670 (QNH28_05670) 1288212..1290440 + 2229 WP_283910534.1 Tex family protein -
QNH28_RS05675 (QNH28_05675) 1290530..1290682 - 153 WP_283910535.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12764.68 Da        Isoelectric Point: 5.1171

>T282605 WP_042124727.1 NZ_CP126095:1285597-1285947 [Paenibacillus sp. G2S3]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAAAHGFDRDSVILLEQV
RTIDKQRLTDKITHLDDETMKKVDDSLQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10626.28 Da        Isoelectric Point: 6.9810

>AT282605 WP_025698676.1 NZ_CP126095:1285312-1285593 [Paenibacillus sp. G2S3]
VANLQNTKRIMISLPDHLLQEVDGIVQLENSNRSELIRQAMKLYLSERRKRSIRESMQRGYMEMAKINLTMACEAFLAEE
DADSTLGRLVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W1B4L6

Antitoxin

Source ID Structure
AlphaFold DB A0A089IDM2

References