282604

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1316734..1317650 Replicon chromosome
Accession NZ_CP126094
Organism Bacillus subtilis strain G2S2

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag QNH31_RS06895 Protein ID WP_003244695.1
Coordinates 1316904..1317650 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag QNH31_RS06890 Protein ID WP_003232646.1
Coordinates 1316734..1316904 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH31_RS06855 (QNH31_06855) 1313597..1313926 + 330 WP_041850928.1 XkdW family protein -
QNH31_RS06860 (QNH31_06860) 1313923..1314087 + 165 WP_041850927.1 XkdX family protein -
QNH31_RS06865 (QNH31_06865) 1314131..1314970 + 840 WP_041850926.1 phage-like element PBSX protein XepA -
QNH31_RS06870 (QNH31_06870) 1315023..1315292 + 270 WP_003232655.1 hemolysin XhlA family protein -
QNH31_RS06875 (QNH31_06875) 1315305..1315568 + 264 WP_003232653.1 phage holin -
QNH31_RS06880 (QNH31_06880) 1315581..1316474 + 894 WP_041850925.1 N-acetylmuramoyl-L-alanine amidase -
QNH31_RS06885 (QNH31_06885) 1316511..1316648 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
QNH31_RS06890 (QNH31_06890) 1316734..1316904 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
QNH31_RS06895 (QNH31_06895) 1316904..1317650 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
QNH31_RS06900 (QNH31_06900) 1317760..1318761 - 1002 WP_003232642.1 inorganic phosphate transporter -
QNH31_RS06905 (QNH31_06905) 1318774..1319391 - 618 WP_003218470.1 DUF47 domain-containing protein -
QNH31_RS06910 (QNH31_06910) 1319667..1320983 - 1317 WP_041850924.1 serine/threonine exchanger -
QNH31_RS06915 (QNH31_06915) 1321371..1322321 + 951 WP_041344800.1 ring-cleaving dioxygenase -
QNH31_RS06920 (QNH31_06920) 1322422..1322568 + 147 WP_120363335.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1282861..1325727 42866


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T282604 WP_003244695.1 NZ_CP126094:c1317650-1316904 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT282604 WP_003232646.1 NZ_CP126094:c1316904-1316734 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
AlphaFold DB G4EXD8

References