282601

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 280510..281149 Replicon chromosome
Accession NZ_CP126092
Organism Peribacillus simplex strain D9_B_73

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag QNH50_RS01470 Protein ID WP_034306610.1
Coordinates 280799..281149 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag QNH50_RS01465 Protein ID WP_034306380.1
Coordinates 280510..280791 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH50_RS01445 (QNH50_01445) 276644..277234 - 591 WP_230302699.1 rhomboid family intramembrane serine protease -
QNH50_RS01450 (QNH50_01450) 277343..277693 + 351 WP_053537119.1 holo-ACP synthase -
QNH50_RS01455 (QNH50_01455) 277938..278942 + 1005 WP_230302698.1 outer membrane lipoprotein carrier protein LolA -
QNH50_RS01460 (QNH50_01460) 279165..280349 + 1185 WP_230302697.1 alanine racemase -
QNH50_RS01465 (QNH50_01465) 280510..280791 + 282 WP_034306380.1 antitoxin EndoAI Antitoxin
QNH50_RS01470 (QNH50_01470) 280799..281149 + 351 WP_034306610.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QNH50_RS01475 (QNH50_01475) 281563..282390 + 828 WP_230302696.1 RsbT co-antagonist protein RsbRA -
QNH50_RS01480 (QNH50_01480) 282393..282749 + 357 WP_230302695.1 STAS domain-containing protein -
QNH50_RS01485 (QNH50_01485) 282753..283154 + 402 WP_214774177.1 anti-sigma regulatory factor -
QNH50_RS01490 (QNH50_01490) 283164..284174 + 1011 WP_230302694.1 PP2C family protein-serine/threonine phosphatase -
QNH50_RS01495 (QNH50_01495) 284234..284566 + 333 WP_098372176.1 anti-sigma factor antagonist -
QNH50_RS01500 (QNH50_01500) 284563..285036 + 474 WP_098372177.1 anti-sigma B factor RsbW -
QNH50_RS01505 (QNH50_01505) 285014..285802 + 789 WP_230302693.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12955.06 Da        Isoelectric Point: 7.2029

>T282601 WP_034306610.1 NZ_CP126092:280799-281149 [Peribacillus simplex]
IVVKRGDVYFADLSPVVGSEQGGTRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEPMMQKVNEALQISLGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10713.13 Da        Isoelectric Point: 5.9054

>AT282601 WP_034306380.1 NZ_CP126092:280510-280791 [Peribacillus simplex]
VSESSATREILIRLPQNFLTELDGYASEENVNRSEFIYRATKMYLRERKKKEFRESMKRGYIEMAAINLTIASEAFQAEF
EAGHCVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References