Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 2538108..2539100 | Replicon | chromosome |
| Accession | NC_018612 | ||
| Organism | Mycobacterium indicus pranii MTCC 9506 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | J9WIQ3 |
| Locus tag | MIP_RS11610 | Protein ID | WP_014941867.1 |
| Coordinates | 2538522..2539100 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | J9WGA7 |
| Locus tag | MIP_RS11605 | Protein ID | WP_014941866.1 |
| Coordinates | 2538108..2538497 (+) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MIP_RS11580 | 2533559..2535562 | + | 2004 | WP_014384640.1 | phosphotransferase | - |
| MIP_RS11585 | 2535559..2536059 | + | 501 | WP_014384641.1 | gluconokinase | - |
| MIP_RS11590 | 2536130..2536741 | - | 612 | WP_009956383.1 | TetR/AcrR family transcriptional regulator | - |
| MIP_RS11595 | 2536911..2537735 | + | 825 | WP_080588061.1 | SAM-dependent methyltransferase | - |
| MIP_RS11600 | 2537775..2538050 | + | 276 | WP_038536176.1 | hypothetical protein | - |
| MIP_RS11605 | 2538108..2538497 | + | 390 | WP_014941866.1 | hypothetical protein | Antitoxin |
| MIP_RS11610 | 2538522..2539100 | + | 579 | WP_014941867.1 | zeta toxin family protein | Toxin |
| MIP_RS11615 | 2539120..2540187 | - | 1068 | WP_014380064.1 | DoxX family membrane protein | - |
| MIP_RS11620 | 2540283..2540843 | + | 561 | WP_158020468.1 | pyrazinamidase PncA | - |
| MIP_RS11625 | 2540843..2541643 | + | 801 | WP_009956375.1 | nuclear transport factor 2 family protein | - |
| MIP_RS11630 | 2541655..2542005 | - | 351 | WP_009956374.1 | DoxX family protein | - |
| MIP_RS11635 | 2542171..2543142 | + | 972 | WP_014941870.1 | sigma-70 family RNA polymerase sigma factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21005.20 Da Isoelectric Point: 11.0232
>T28260 WP_014941867.1 NC_018612:2538522-2539100 [Mycobacterium intracellulare subsp. intracellulare MTCC 9506]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGDAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTALRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNGRLRG
PRIVARLSGGMIIGSPDWPAWAPEILRSRWPD
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGDAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTALRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNGRLRG
PRIVARLSGGMIIGSPDWPAWAPEILRSRWPD
Download Length: 579 bp
>T28260 NC_018612:2538522-2539100 [Mycobacterium intracellulare subsp. intracellulare MTCC 9506]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACGCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGATGCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCTCCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTTTCCGACGTCGCCACCGTCTACGACAACGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGATTATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACGCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGATGCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCTCCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTTTCCGACGTCGCCACCGTCTACGACAACGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGATTATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG
Antitoxin
Download Length: 130 a.a. Molecular weight: 13484.84 Da Isoelectric Point: 5.1743
>AT28260 WP_014941866.1 NC_018612:2538108-2538497 [Mycobacterium intracellulare subsp. intracellulare MTCC 9506]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEV
SAAIDESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEV
SAAIDESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR
Download Length: 390 bp
>AT28260 NC_018612:2538108-2538497 [Mycobacterium intracellulare subsp. intracellulare MTCC 9506]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGGTC
TCCGCGGCCATCGACGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGACGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGGTC
TCCGCGGCCATCGACGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGACGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|