Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 571443..572079 Replicon chromosome
Accession NZ_CP126091
Organism Bacillus paralicheniformis strain CEW 1W

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag QNH18_RS02850 Protein ID WP_003179128.1
Coordinates 571729..572079 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag QNH18_RS02845 Protein ID WP_006638778.1
Coordinates 571443..571724 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH18_RS02825 (QNH18_02825) 566554..568038 + 1485 WP_023857868.1 PH domain-containing protein -
QNH18_RS02830 (QNH18_02830) 568035..568634 - 600 WP_023857867.1 rhomboid family intramembrane serine protease -
QNH18_RS02835 (QNH18_02835) 568978..569937 + 960 WP_164468292.1 outer membrane lipoprotein carrier protein LolA -
QNH18_RS02840 (QNH18_02840) 570162..571331 + 1170 WP_219192348.1 alanine racemase -
QNH18_RS02845 (QNH18_02845) 571443..571724 + 282 WP_006638778.1 hypothetical protein Antitoxin
QNH18_RS02850 (QNH18_02850) 571729..572079 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QNH18_RS02855 (QNH18_02855) 572197..573024 + 828 WP_023857863.1 RsbT co-antagonist protein RsbRA -
QNH18_RS02860 (QNH18_02860) 573028..573393 + 366 WP_031305225.1 STAS domain-containing protein -
QNH18_RS02865 (QNH18_02865) 573396..573797 + 402 WP_023857861.1 anti-sigma regulatory factor -
QNH18_RS02870 (QNH18_02870) 573808..574815 + 1008 WP_020450261.1 PP2C family protein-serine/threonine phosphatase -
QNH18_RS02875 (QNH18_02875) 574874..575200 + 327 WP_020450262.1 anti-sigma factor antagonist -
QNH18_RS02880 (QNH18_02880) 575200..575682 + 483 WP_020450263.1 anti-sigma B factor RsbW -
QNH18_RS02885 (QNH18_02885) 575648..576439 + 792 WP_023857858.1 RNA polymerase sigma factor SigB -
QNH18_RS02890 (QNH18_02890) 576436..577035 + 600 WP_035337155.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T282599 WP_003179128.1 NZ_CP126091:571729-572079 [Bacillus paralicheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT282599 WP_006638778.1 NZ_CP126091:571443-571724 [Bacillus paralicheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References