Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 530839..531475 Replicon chromosome
Accession NZ_CP126087
Organism Bacillus safensis strain CEW-AP100

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag QNH25_RS02560 Protein ID WP_024425388.1
Coordinates 531125..531475 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag QNH25_RS02555 Protein ID WP_003214273.1
Coordinates 530839..531120 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH25_RS02535 (QNH25_02535) 526979..527584 - 606 WP_024425384.1 rhomboid family intramembrane serine protease -
QNH25_RS02540 (QNH25_02540) 527679..528044 + 366 WP_047202005.1 holo-ACP synthase -
QNH25_RS02545 (QNH25_02545) 528205..529221 + 1017 WP_087975235.1 outer membrane lipoprotein-sorting protein -
QNH25_RS02550 (QNH25_02550) 529363..530544 + 1182 WP_044334720.1 alanine racemase -
QNH25_RS02555 (QNH25_02555) 530839..531120 + 282 WP_003214273.1 hypothetical protein Antitoxin
QNH25_RS02560 (QNH25_02560) 531125..531475 + 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QNH25_RS02565 (QNH25_02565) 531592..532422 + 831 WP_044334717.1 RsbT co-antagonist protein RsbRA -
QNH25_RS02570 (QNH25_02570) 532427..532795 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
QNH25_RS02575 (QNH25_02575) 532798..533199 + 402 WP_073203956.1 anti-sigma regulatory factor -
QNH25_RS02580 (QNH25_02580) 533210..534217 + 1008 WP_024425391.1 PP2C family protein-serine/threonine phosphatase -
QNH25_RS02585 (QNH25_02585) 534277..534606 + 330 WP_024425392.1 anti-sigma factor antagonist -
QNH25_RS02590 (QNH25_02590) 534603..535091 + 489 WP_024425393.1 anti-sigma B factor RsbW -
QNH25_RS02595 (QNH25_02595) 535057..535845 + 789 WP_024425394.1 RNA polymerase sigma factor SigB -
QNH25_RS02600 (QNH25_02600) 535845..536444 + 600 WP_024425395.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T282595 WP_024425388.1 NZ_CP126087:531125-531475 [Bacillus safensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT282595 WP_003214273.1 NZ_CP126087:530839-531120 [Bacillus safensis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References