Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 546453..547089 Replicon chromosome
Accession NZ_CP126086
Organism Bacillus altitudinis strain CES-OCA-19

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag QNH40_RS02640 Protein ID WP_003214169.1
Coordinates 546739..547089 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag QNH40_RS02635 Protein ID WP_003214273.1
Coordinates 546453..546734 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH40_RS02615 (QNH40_02615) 542610..543212 - 603 WP_283931231.1 rhomboid family intramembrane serine protease -
QNH40_RS02620 (QNH40_02620) 543307..543672 + 366 WP_019744212.1 holo-ACP synthase -
QNH40_RS02625 (QNH40_02625) 543833..544849 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
QNH40_RS02630 (QNH40_02630) 544978..546159 + 1182 WP_283931232.1 alanine racemase -
QNH40_RS02635 (QNH40_02635) 546453..546734 + 282 WP_003214273.1 hypothetical protein Antitoxin
QNH40_RS02640 (QNH40_02640) 546739..547089 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QNH40_RS02645 (QNH40_02645) 547204..548034 + 831 WP_007496484.1 RsbT co-antagonist protein RsbRA -
QNH40_RS02650 (QNH40_02650) 548039..548407 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
QNH40_RS02655 (QNH40_02655) 548410..548811 + 402 WP_003214085.1 anti-sigma regulatory factor -
QNH40_RS02660 (QNH40_02660) 548822..549829 + 1008 WP_008346904.1 PP2C family protein-serine/threonine phosphatase -
QNH40_RS02665 (QNH40_02665) 549889..550218 + 330 WP_008346902.1 anti-sigma factor antagonist -
QNH40_RS02670 (QNH40_02670) 550215..550703 + 489 WP_007496471.1 anti-sigma B factor RsbW -
QNH40_RS02675 (QNH40_02675) 550669..551457 + 789 WP_025206796.1 RNA polymerase sigma factor SigB -
QNH40_RS02680 (QNH40_02680) 551457..552056 + 600 WP_008346897.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T282594 WP_003214169.1 NZ_CP126086:546739-547089 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT282594 WP_003214273.1 NZ_CP126086:546453-546734 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References