Detailed information of TA system TA028259

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 2219258..2219922
• Replicon: chromosome
• Accession: NC_018612
• Organism: Mycobacterium indicus pranii MTCC 9506

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: J9WD27
• Locus tag: MIP_RS10270
• Protein ID: WP_009954498.1
• Coordinates: 2219515..2219922 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MIP_RS26110
• Protein ID: WP_083862994.1
• Coordinates: 2219258..2219518 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MIP_RS10250	2215773..2216264	-	492	WP_014941753.1	DUF1707 domain-containing protein	-
MIP_RS10255	2216334..2216930	+	597	WP_043954743.1	TetR/AcrR family transcriptional regulator	-
MIP_RS10260	2216935..2218203	-	1269	WP_014941755.1	cytochrome P450	-
MIP_RS10265	2218361..2218813	+	453	WP_014941756.1	VOC family protein	-
MIP_RS26110	2219258..2219518	+	261	WP_083862994.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MIP_RS10270	2219515..2219922	+	408	WP_009954498.1	type II toxin-antitoxin system VapC family toxin	Toxin
MIP_RS10275	2220100..2222211	+	2112	Protein_2046	DEAD/DEAH box helicase family protein	-
MIP_RS10280	2222350..2223711	+	1362	WP_014940946.1	DDE-type integrase/transposase/recombinase	-
MIP_RS10285	2223708..2224559	+	852	WP_014941758.1	IS21-like element helper ATPase IstB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-125)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-66)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14293.28 Da
• Isoelectric Point: 4.2772

>T28259 WP_009954498.1 NC_018612:2219515-2219922 [Mycobacterium intracellulare subsp. intracellulare MTCC 9506]
MSNPQVAGVLDTSVFIATESGRPLDAALIPDQVGTTVVTLAELHVGVLAASTSDIRAQRLATLESIADIEALPVDDDAAR
MWARLRIHLAETGQRVRINDLWIAAIAASRGLPVVTQDDDFAVLDGAANLTVIRV

Nucleotide

• Length: 408 bp

>T28259 NC_018612:2219515-2219922 [Mycobacterium intracellulare subsp. intracellulare MTCC 9506]
ATGAGCAACCCGCAGGTGGCCGGAGTGCTCGACACTTCGGTGTTCATCGCGACCGAAAGTGGTCGGCCTCTCGACGCGGC
GCTGATCCCTGATCAAGTTGGCACTACGGTTGTTACCCTCGCGGAACTGCACGTTGGTGTGTTGGCCGCGTCGACTTCCG
ATATTAGAGCGCAGCGCCTCGCGACATTGGAATCCATTGCGGATATCGAAGCGCTGCCGGTCGATGACGATGCGGCCCGG
ATGTGGGCCCGGCTGCGGATCCATCTCGCCGAGACCGGTCAACGCGTCCGGATCAACGATCTGTGGATCGCGGCCATCGC
GGCGTCCCGAGGGCTACCTGTTGTCACGCAGGACGATGACTTTGCCGTCTTGGATGGTGCGGCCAATTTGACCGTTATCC
GCGTCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9525.87 Da
• Isoelectric Point: 10.9921

>AT28259 WP_083862994.1 NC_018612:2219258-2219518 [Mycobacterium intracellulare subsp. intracellulare MTCC 9506]
MSEVASRELRNDTAGVLRRVRDGEDVTITVSGRPVAVLTAVVPQRRRWLSKTELLSRLPRVQADPGLREDLHALAGDTTE
QLGPIR

Nucleotide

• Length: 261 bp

>AT28259 NC_018612:2219258-2219518 [Mycobacterium intracellulare subsp. intracellulare MTCC 9506]
ATGTCTGAAGTGGCATCTCGTGAGCTGCGCAACGATACGGCTGGGGTGCTGCGGCGGGTTCGGGATGGAGAGGACGTCAC
CATCACTGTCAGTGGCCGACCGGTCGCAGTTCTTACCGCAGTTGTCCCTCAGCGCAGGCGTTGGCTGAGCAAGACGGAGT
TGCTGTCGCGCTTGCCCCGCGTTCAAGCGGATCCGGGATTACGCGAGGACCTTCACGCACTCGCCGGCGACACTACCGAG
CAGCTGGGCCCAATCCGATGA

Structures

Toxin

• AlphaFold DB: J9WD27