Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1316948..1317864 Replicon chromosome
Accession NZ_CP126082
Organism Bacillus subtilis strain C1_13

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag QNH30_RS06910 Protein ID WP_003244695.1
Coordinates 1317118..1317864 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag QNH30_RS06905 Protein ID WP_003232646.1
Coordinates 1316948..1317118 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH30_RS06870 (QNH30_06870) 1313811..1314140 + 330 WP_041850928.1 XkdW family protein -
QNH30_RS06875 (QNH30_06875) 1314137..1314301 + 165 WP_041850927.1 XkdX family protein -
QNH30_RS06880 (QNH30_06880) 1314345..1315184 + 840 WP_041850926.1 phage-like element PBSX protein XepA -
QNH30_RS06885 (QNH30_06885) 1315237..1315506 + 270 WP_003232655.1 hemolysin XhlA family protein -
QNH30_RS06890 (QNH30_06890) 1315519..1315782 + 264 WP_003232653.1 phage holin -
QNH30_RS06895 (QNH30_06895) 1315795..1316688 + 894 WP_041850925.1 N-acetylmuramoyl-L-alanine amidase -
QNH30_RS06900 (QNH30_06900) 1316725..1316862 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
QNH30_RS06905 (QNH30_06905) 1316948..1317118 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
QNH30_RS06910 (QNH30_06910) 1317118..1317864 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
QNH30_RS06915 (QNH30_06915) 1317974..1318975 - 1002 WP_003232642.1 inorganic phosphate transporter -
QNH30_RS06920 (QNH30_06920) 1318988..1319605 - 618 WP_003218470.1 DUF47 domain-containing protein -
QNH30_RS06925 (QNH30_06925) 1319881..1321197 - 1317 WP_041850924.1 serine/threonine exchanger -
QNH30_RS06930 (QNH30_06930) 1321585..1322535 + 951 WP_041344800.1 ring-cleaving dioxygenase -
QNH30_RS06935 (QNH30_06935) 1322636..1322782 + 147 WP_120363335.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1283075..1325941 42866


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T282589 WP_003244695.1 NZ_CP126082:c1317864-1317118 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT282589 WP_003232646.1 NZ_CP126082:c1317118-1316948 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References