Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 236532..237168 Replicon chromosome
Accession NZ_CP126080
Organism Mesobacillus sp. AQ2

Toxin (Protein)


Gene name mazF Uniprot ID A0A3Q9QS43
Locus tag QNH36_RS01280 Protein ID WP_041967053.1
Coordinates 236818..237168 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID W4RP20
Locus tag QNH36_RS01275 Protein ID WP_031308192.1
Coordinates 236532..236813 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH36_RS01255 (QNH36_01255) 232583..233167 - 585 WP_144481172.1 rhomboid family intramembrane serine protease -
QNH36_RS01260 (QNH36_01260) 233315..233668 + 354 WP_251544793.1 holo-ACP synthase -
QNH36_RS01265 (QNH36_01265) 233860..234873 + 1014 WP_283904492.1 outer membrane lipoprotein carrier protein LolA -
QNH36_RS01270 (QNH36_01270) 235181..236338 + 1158 WP_251544792.1 alanine racemase -
QNH36_RS01275 (QNH36_01275) 236532..236813 + 282 WP_031308192.1 hypothetical protein Antitoxin
QNH36_RS01280 (QNH36_01280) 236818..237168 + 351 WP_041967053.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QNH36_RS01285 (QNH36_01285) 237803..238636 + 834 WP_144481164.1 RsbT co-antagonist protein RsbRA -
QNH36_RS01290 (QNH36_01290) 238633..238989 + 357 WP_041967776.1 STAS domain-containing protein -
QNH36_RS01295 (QNH36_01295) 238994..239395 + 402 WP_144481162.1 anti-sigma regulatory factor -
QNH36_RS01300 (QNH36_01300) 239407..240417 + 1011 WP_144481160.1 PP2C family protein-serine/threonine phosphatase -
QNH36_RS01305 (QNH36_01305) 240476..240808 + 333 WP_144481158.1 anti-sigma factor antagonist -
QNH36_RS01310 (QNH36_01310) 240805..241278 + 474 WP_283904493.1 anti-sigma B factor RsbW -
QNH36_RS01315 (QNH36_01315) 241256..242050 + 795 WP_144481156.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13020.06 Da        Isoelectric Point: 4.8998

>T282586 WP_041967053.1 NZ_CP126080:236818-237168 [Mesobacillus sp. AQ2]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10753.28 Da        Isoelectric Point: 7.2035

>AT282586 WP_031308192.1 NZ_CP126080:236532-236813 [Mesobacillus sp. AQ2]
VSESSATTEILVKLPQHLLSELDGFVKQENVNRSEFIYQATKMFLREKKKRQIRESMRRGYMEMAKINLTIASEAFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q9QS43

Antitoxin

Source ID Structure
AlphaFold DB W4RP20

References