Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 1504993..1505631 Replicon chromosome
Accession NZ_CP126079
Organism Paenibacillus polymyxa strain ACCC03434

Toxin (Protein)


Gene name pemK Uniprot ID H6CFY1
Locus tag QNH38_RS06370 Protein ID WP_007429335.1
Coordinates 1505281..1505631 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H6CFY0
Locus tag QNH38_RS06365 Protein ID WP_007429334.1
Coordinates 1504993..1505274 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH38_RS06345 (QNH38_06345) 1500010..1500981 - 972 WP_167440839.1 ABC transporter substrate-binding protein -
QNH38_RS06350 (QNH38_06350) 1501216..1501848 + 633 WP_031463107.1 LysE family transporter -
QNH38_RS06355 (QNH38_06355) 1501959..1503236 + 1278 WP_031463108.1 outer membrane lipoprotein-sorting protein -
QNH38_RS06360 (QNH38_06360) 1503503..1504699 + 1197 WP_031463109.1 alanine racemase -
QNH38_RS06365 (QNH38_06365) 1504993..1505274 + 282 WP_007429334.1 ribbon-helix-helix protein, CopG family Antitoxin
QNH38_RS06370 (QNH38_06370) 1505281..1505631 + 351 WP_007429335.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QNH38_RS06375 (QNH38_06375) 1505810..1508032 + 2223 WP_017426526.1 Tex family protein -
QNH38_RS06380 (QNH38_06380) 1508131..1508265 - 135 WP_016821163.1 cortex morphogenetic protein CmpA -
QNH38_RS06385 (QNH38_06385) 1508408..1508920 + 513 WP_016821162.1 SprT family protein -
QNH38_RS06400 (QNH38_06400) 1509299..1510174 - 876 WP_031463111.1 Cof-type HAD-IIB family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12822.77 Da        Isoelectric Point: 5.6195

>T282585 WP_007429335.1 NZ_CP126079:1505281-1505631 [Paenibacillus polymyxa]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAATHGFDRDSVVLLEQI
RTIDKQRLTDKITHLDEETMRKVSDSLQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10636.25 Da        Isoelectric Point: 8.5257

>AT282585 WP_007429334.1 NZ_CP126079:1504993-1505274 [Paenibacillus polymyxa]
MANLQNTKRIMISLPDHLLQEVDGIVAMENSNRSEFIRQAMKLYVGERKKRYIREAMQRGYMEMAKINLTMASEAFHAEE
DANSTLGRTVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H6CFY1

Antitoxin

Source ID Structure
AlphaFold DB H6CFY0

References