Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2729862..2730510 Replicon chromosome
Accession NZ_CP126077
Organism Virgibacillus halodenitrificans strain ACCC02857

Toxin (Protein)


Gene name mazF Uniprot ID A0A6L8JWB3
Locus tag QNH47_RS13495 Protein ID WP_019379217.1
Coordinates 2729862..2730221 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag QNH47_RS13500 Protein ID WP_019379218.1
Coordinates 2730226..2730510 (-) Length 95 a.a.

Genomic Context

QNH47_RS13460QNH47_RS13465QNH47_RS13470QNH47_RS13475QNH47_RS13480QNH47_RS13485QNH47_RS13490QNH47_RS13495QNH47_RS13500QNH47_RS13505QNH47_RS13510QNH47_RS13515QNH47_RS13520
Location: 2725078..2725869 (792 bp)
Type: Others
Protein ID: WP_060681900.1
Location: 2725841..2726317 (477 bp)
Type: Others
Protein ID: WP_019379211.1
Location: 2726317..2726649 (333 bp)
Type: Others
Protein ID: WP_019379212.1
Location: 2726755..2727768 (1014 bp)
Type: Others
Protein ID: WP_019379213.1
Location: 2727876..2728277 (402 bp)
Type: Others
Protein ID: WP_121615802.1
Location: 2728280..2728636 (357 bp)
Type: Others
Protein ID: WP_019379215.1
Location: 2728642..2729511 (870 bp)
Type: Others
Protein ID: WP_160804815.1
Location: 2729862..2730221 (360 bp)
Type: Toxin
Protein ID: WP_019379217.1
Location: 2730226..2730510 (285 bp)
Type: Antitoxin
Protein ID: WP_019379218.1
Location: 2730673..2731797 (1125 bp)
Type: Others
Protein ID: WP_283872873.1
Location: 2731988..2732998 (1011 bp)
Type: Others
Protein ID: WP_283872874.1
Location: 2733086..2734606 (1521 bp)
Type: Others
Protein ID: WP_283872876.1
Location: 2734666..2735025 (360 bp)
Type: Others
Protein ID: WP_060681891.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QNH47_RS13460 (QNH47_13460)2725078..2725869-792WP_060681900.1RNA polymerase sigma factor SigB-
QNH47_RS13465 (QNH47_13465)2725841..2726317-477WP_019379211.1anti-sigma B factor RsbW-
QNH47_RS13470 (QNH47_13470)2726317..2726649-333WP_019379212.1STAS domain-containing protein-
QNH47_RS13475 (QNH47_13475)2726755..2727768-1014WP_019379213.1PP2C family protein-serine/threonine phosphatase-
QNH47_RS13480 (QNH47_13480)2727876..2728277-402WP_121615802.1anti-sigma regulatory factor-
QNH47_RS13485 (QNH47_13485)2728280..2728636-357WP_019379215.1STAS domain-containing protein-
QNH47_RS13490 (QNH47_13490)2728642..2729511-870WP_160804815.1RsbT co-antagonist protein RsbRA-
QNH47_RS13495 (QNH47_13495)2729862..2730221-360WP_019379217.1type II toxin-antitoxin system PemK/MazF family toxinToxin
QNH47_RS13500 (QNH47_13500)2730226..2730510-285WP_019379218.1hypothetical proteinAntitoxin
QNH47_RS13505 (QNH47_13505)2730673..2731797-1125WP_283872873.1alanine racemase-
QNH47_RS13510 (QNH47_13510)2731988..2732998-1011WP_283872874.1outer membrane lipoprotein carrier protein LolA-
QNH47_RS13515 (QNH47_13515)2733086..2734606-1521WP_283872876.1NAD(P)H-hydrate dehydratase-
QNH47_RS13520 (QNH47_13520)2734666..2735025-360WP_060681891.1holo-ACP synthase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13377.53 Da        Isoelectric Point: 8.4940

>T282583 WP_019379217.1 NZ_CP126077:c2730221-2729862 [Virgibacillus halodenitrificans]
MIVQRGEVYFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKRYGFDRNSVILLEQI
RTLDKQRLTDKITKLDAEMMNKINQALEISLGLKDMYDH

Download         Length: 360 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10910.24 Da        Isoelectric Point: 4.3735

>AT282583 WP_019379218.1 NZ_CP126077:c2730510-2730226 [Virgibacillus halodenitrificans]
MSESLQEILVKIPKNLLNEVDGLMRYENSDLSDFICQATRSYLQHKKDEHIQQFRETMQKGYEEMGRINLTIASEAFQAE
EEAENTLERSVIGV

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A6L8JWB3

Antitoxin

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Source
ID
Structure
No matching records found

References