282583

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2729862..2730510 Replicon chromosome
Accession NZ_CP126077
Organism Virgibacillus halodenitrificans strain ACCC02857

Toxin (Protein)


Gene name mazF Uniprot ID A0A6L8JWB3
Locus tag QNH47_RS13495 Protein ID WP_019379217.1
Coordinates 2729862..2730221 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag QNH47_RS13500 Protein ID WP_019379218.1
Coordinates 2730226..2730510 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH47_RS13460 (QNH47_13460) 2725078..2725869 - 792 WP_060681900.1 RNA polymerase sigma factor SigB -
QNH47_RS13465 (QNH47_13465) 2725841..2726317 - 477 WP_019379211.1 anti-sigma B factor RsbW -
QNH47_RS13470 (QNH47_13470) 2726317..2726649 - 333 WP_019379212.1 STAS domain-containing protein -
QNH47_RS13475 (QNH47_13475) 2726755..2727768 - 1014 WP_019379213.1 PP2C family protein-serine/threonine phosphatase -
QNH47_RS13480 (QNH47_13480) 2727876..2728277 - 402 WP_121615802.1 anti-sigma regulatory factor -
QNH47_RS13485 (QNH47_13485) 2728280..2728636 - 357 WP_019379215.1 STAS domain-containing protein -
QNH47_RS13490 (QNH47_13490) 2728642..2729511 - 870 WP_160804815.1 RsbT co-antagonist protein RsbRA -
QNH47_RS13495 (QNH47_13495) 2729862..2730221 - 360 WP_019379217.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QNH47_RS13500 (QNH47_13500) 2730226..2730510 - 285 WP_019379218.1 hypothetical protein Antitoxin
QNH47_RS13505 (QNH47_13505) 2730673..2731797 - 1125 WP_283872873.1 alanine racemase -
QNH47_RS13510 (QNH47_13510) 2731988..2732998 - 1011 WP_283872874.1 outer membrane lipoprotein carrier protein LolA -
QNH47_RS13515 (QNH47_13515) 2733086..2734606 - 1521 WP_283872876.1 NAD(P)H-hydrate dehydratase -
QNH47_RS13520 (QNH47_13520) 2734666..2735025 - 360 WP_060681891.1 holo-ACP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13377.53 Da        Isoelectric Point: 8.4940

>T282583 WP_019379217.1 NZ_CP126077:c2730221-2729862 [Virgibacillus halodenitrificans]
MIVQRGEVYFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKRYGFDRNSVILLEQI
RTLDKQRLTDKITKLDAEMMNKINQALEISLGLKDMYDH

Download         Length: 360 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10910.24 Da        Isoelectric Point: 4.3735

>AT282583 WP_019379218.1 NZ_CP126077:c2730510-2730226 [Virgibacillus halodenitrificans]
MSESLQEILVKIPKNLLNEVDGLMRYENSDLSDFICQATRSYLQHKKDEHIQQFRETMQKGYEEMGRINLTIASEAFQAE
EEAENTLERSVIGV

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L8JWB3

Antitoxin

Source ID Structure

References