Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4553448..4554105 Replicon chromosome
Accession NZ_CP126058
Organism Klebsiella pneumoniae subsp. pneumoniae strain CS00491

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QM175_RS21925 Protein ID WP_002916310.1
Coordinates 4553448..4553858 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QM175_RS21930 Protein ID WP_002916312.1
Coordinates 4553839..4554105 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM175_RS21905 (4549448) 4549448..4551181 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
QM175_RS21910 (4551187) 4551187..4551900 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QM175_RS21915 (4551923) 4551923..4552819 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QM175_RS21920 (4552920) 4552920..4553441 + 522 WP_002916308.1 flavodoxin FldB -
QM175_RS21925 (4553448) 4553448..4553858 - 411 WP_002916310.1 protein YgfX Toxin
QM175_RS21930 (4553839) 4553839..4554105 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QM175_RS21935 (4554351) 4554351..4555334 + 984 WP_283903528.1 tRNA-modifying protein YgfZ -
QM175_RS21940 (4555433) 4555433..4556092 - 660 WP_004174454.1 hemolysin III family protein -
QM175_RS21945 (4556256) 4556256..4556567 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
QM175_RS21950 (4556617) 4556617..4557345 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QM175_RS21955 (4557464) 4557464..4558897 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T282538 WP_002916310.1 NZ_CP126058:c4553858-4553448 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT282538 WP_002916312.1 NZ_CP126058:c4554105-4553839 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References