Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2623007..2624595 Replicon chromosome
Accession NZ_CP126058
Organism Klebsiella pneumoniae subsp. pneumoniae strain CS00491

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag QM175_RS12560 Protein ID WP_004892016.1
Coordinates 2623273..2624595 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QM175_RS12555 Protein ID WP_004176198.1
Coordinates 2623007..2623273 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM175_RS12530 (2618036) 2618036..2618959 + 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -
QM175_RS12535 (2618940) 2618940..2620094 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QM175_RS12540 (2620440) 2620440..2621819 + 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
QM175_RS12545 (2621797) 2621797..2622297 + 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QM175_RS12550 (2622294) 2622294..2622620 + 327 WP_004184023.1 hydroxyisourate hydrolase -
QM175_RS12555 (2623007) 2623007..2623273 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QM175_RS12560 (2623273) 2623273..2624595 + 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
QM175_RS12565 (2624612) 2624612..2625904 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QM175_RS12570 (2626046) 2626046..2627049 - 1004 Protein_2442 fimbrial protein -
QM175_RS12575 (2627037) 2627037..2629538 - 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T282532 WP_004892016.1 NZ_CP126058:2623273-2624595 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT282532 WP_004176198.1 NZ_CP126058:2623007-2623273 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References