Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1294157..1294776 Replicon chromosome
Accession NZ_CP126058
Organism Klebsiella pneumoniae subsp. pneumoniae strain CS00491

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag QM175_RS06125 Protein ID WP_002892050.1
Coordinates 1294157..1294375 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag QM175_RS06130 Protein ID WP_002892066.1
Coordinates 1294402..1294776 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM175_RS06090 (1290204) 1290204..1290467 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
QM175_RS06095 (1290467) 1290467..1290607 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
QM175_RS06100 (1290604) 1290604..1291302 - 699 WP_032435564.1 GNAT family protein -
QM175_RS06105 (1291403) 1291403..1292854 + 1452 WP_032435563.1 PLP-dependent aminotransferase family protein -
QM175_RS06110 (1292829) 1292829..1293299 - 471 WP_002892026.1 YlaC family protein -
QM175_RS06115 (1293320) 1293320..1293460 + 141 WP_004147370.1 hypothetical protein -
QM175_RS06120 (1293432) 1293432..1293998 - 567 WP_002892030.1 maltose O-acetyltransferase -
QM175_RS06125 (1294157) 1294157..1294375 - 219 WP_002892050.1 HHA domain-containing protein Toxin
QM175_RS06130 (1294402) 1294402..1294776 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
QM175_RS06135 (1295262) 1295262..1298408 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
QM175_RS06140 (1298431) 1298431..1299624 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T282531 WP_002892050.1 NZ_CP126058:c1294375-1294157 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT282531 WP_002892066.1 NZ_CP126058:c1294776-1294402 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References