Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 621710..622413 Replicon chromosome
Accession NZ_CP126058
Organism Klebsiella pneumoniae subsp. pneumoniae strain CS00491

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag QM175_RS02910 Protein ID WP_071994632.1
Coordinates 622072..622413 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag QM175_RS02905 Protein ID WP_032434296.1
Coordinates 621710..622051 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM175_RS02870 (616865) 616865..617739 + 875 Protein_540 GTPase family protein -
QM175_RS02875 (617983) 617983..618699 + 717 WP_032434305.1 WYL domain-containing protein -
QM175_RS02880 (618735) 618735..619187 + 453 WP_032410767.1 hypothetical protein -
QM175_RS02885 (619259) 619259..619732 + 474 WP_032434303.1 hypothetical protein -
QM175_RS02890 (619852) 619852..620673 + 822 WP_032434301.1 DUF932 domain-containing protein -
QM175_RS02895 (620704) 620704..621144 + 441 WP_032434300.1 antirestriction protein -
QM175_RS02900 (621157) 621157..621699 + 543 WP_032434298.1 DNA repair protein RadC -
QM175_RS02905 (621710) 621710..622051 + 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QM175_RS02910 (622072) 622072..622413 + 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
QM175_RS02915 (622605) 622605..624638 - 2034 WP_050598589.1 hypothetical protein -
QM175_RS02920 (625229) 625229..626098 - 870 WP_023317468.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 589118..634694 45576


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T282529 WP_071994632.1 NZ_CP126058:622072-622413 [Klebsiella pneumoniae subsp. pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT282529 WP_032434296.1 NZ_CP126058:621710-622051 [Klebsiella pneumoniae subsp. pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References