Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1570104..1570705 Replicon chromosome
Accession NZ_CP126055
Organism Pasteurella multocida strain P030653/1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QNN13_RS07575 Protein ID WP_078819687.1
Coordinates 1570104..1570418 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QNN13_RS07580 Protein ID WP_078819686.1
Coordinates 1570415..1570705 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNN13_RS07535 (QNN13_07535) 1565329..1565697 - 369 Protein_1447 Bro-N domain-containing protein -
QNN13_RS07540 (QNN13_07540) 1566101..1566757 - 657 WP_014390711.1 Bro-N domain-containing protein -
QNN13_RS07545 (QNN13_07545) 1567042..1567878 - 837 WP_014390712.1 KilA-N domain-containing protein -
QNN13_RS07550 (QNN13_07550) 1567989..1568366 - 378 WP_014390713.1 hypothetical protein -
QNN13_RS07555 (QNN13_07555) 1568341..1568532 - 192 WP_014390714.1 hypothetical protein -
QNN13_RS07570 (QNN13_07570) 1569419..1569646 - 228 WP_099821843.1 hypothetical protein -
QNN13_RS07575 (QNN13_07575) 1570104..1570418 + 315 WP_078819687.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QNN13_RS07580 (QNN13_07580) 1570415..1570705 + 291 WP_078819686.1 putative addiction module antidote protein Antitoxin
QNN13_RS07585 (QNN13_07585) 1570731..1571135 - 405 WP_146024473.1 hypothetical protein -
QNN13_RS07590 (QNN13_07590) 1571165..1573009 - 1845 WP_265362803.1 DEAD/DEAH box helicase family protein -
QNN13_RS07595 (QNN13_07595) 1573220..1573897 - 678 WP_014390718.1 XRE family transcriptional regulator -
QNN13_RS07600 (QNN13_07600) 1574021..1574218 + 198 WP_014390719.1 helix-turn-helix domain-containing protein -
QNN13_RS07605 (QNN13_07605) 1574268..1574720 + 453 WP_014390720.1 hypothetical protein -
QNN13_RS07610 (QNN13_07610) 1574779..1575480 + 702 WP_014667788.1 phage antirepressor KilAC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1546029..1599821 53792


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11763.65 Da        Isoelectric Point: 9.5553

>T282524 WP_078819687.1 NZ_CP126055:1570104-1570418 [Pasteurella multocida]
MLDIIETTVFNKWLKELKDLSAKAAILARISRAKSGNFGDHKSVGDGLYEMRIMKGAGYRVYYAQYKDVTYLLICGGDKS
TQKADIAKAKALWEEIKQKEEINV

Download         Length: 315 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10574.22 Da        Isoelectric Point: 5.7134

>AT282524 WP_078819686.1 NZ_CP126055:1570415-1570705 [Pasteurella multocida]
MSKKVELKPFDIAEYLDSEEMIAAYLSEILETGDTNEFISALGDVARARGMTELAAKTGLGRESLYKTLSHGSKPRFDTI
MKITQALGIKLVPTHI

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References