Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 968007..968581 Replicon chromosome
Accession NZ_CP126055
Organism Pasteurella multocida strain P030653/1

Toxin (Protein)


Gene name PumA Uniprot ID A0A849CFF7
Locus tag QNN13_RS04760 Protein ID WP_014667974.1
Coordinates 968297..968581 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A849CG04
Locus tag QNN13_RS04755 Protein ID WP_014391174.1
Coordinates 968007..968300 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNN13_RS04735 (QNN13_04735) 963173..964264 - 1092 WP_005756839.1 L-ascorbate 6-phosphate lactonase -
QNN13_RS04740 (QNN13_04740) 964613..966403 + 1791 WP_014391171.1 PTS ascorbate-specific subunit IIBC -
QNN13_RS04745 (QNN13_04745) 966448..966915 + 468 WP_014391172.1 PTS sugar transporter subunit IIA -
QNN13_RS04750 (QNN13_04750) 966933..967610 + 678 WP_014391173.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
QNN13_RS04755 (QNN13_04755) 968007..968300 - 294 WP_014391174.1 putative addiction module antidote protein Antitoxin
QNN13_RS04760 (QNN13_04760) 968297..968581 - 285 WP_014667974.1 addiction module protein Toxin
QNN13_RS04770 (QNN13_04770) 969875..970136 - 262 Protein_907 hypothetical protein -
QNN13_RS04775 (QNN13_04775) 970480..970632 - 153 WP_014391177.1 hypothetical protein -
QNN13_RS04780 (QNN13_04780) 970932..973118 - 2187 WP_014667973.1 S8 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 969875..970036 161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-85)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10702.41 Da        Isoelectric Point: 10.2849

>T282523 WP_014667974.1 NZ_CP126055:c968581-968297 [Pasteurella multocida]
VGRLREVKNLSAKAAVLARINRVMNGNLGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.80 Da        Isoelectric Point: 8.9149

>AT282523 WP_014391174.1 NZ_CP126055:c968300-968007 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALADVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKITHSLGIKLVPTHI

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A849CFF7

Antitoxin

Source ID Structure
AlphaFold DB A0A849CG04

References