Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 248486..249128 Replicon chromosome
Accession NZ_CP125989
Organism Bacillus cereus strain FFI_gr_46

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag QM225_RS01405 Protein ID WP_000635963.1
Coordinates 248778..249128 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag QM225_RS01400 Protein ID WP_000004570.1
Coordinates 248486..248773 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM225_RS01375 (QM225_000275) 243802..244764 + 963 WP_000961155.1 UV DNA damage repair endonuclease UvsE -
QM225_RS01380 (QM225_000276) 244757..245329 - 573 WP_000906926.1 rhomboid family intramembrane serine protease -
QM225_RS01385 (QM225_000277) 245422..245781 + 360 WP_000635040.1 holo-ACP synthase -
QM225_RS01390 (QM225_000278) 245938..246888 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
QM225_RS01395 (QM225_000279) 247007..248176 + 1170 WP_075396319.1 alanine racemase -
QM225_RS01400 (QM225_000280) 248486..248773 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
QM225_RS01405 (QM225_000281) 248778..249128 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QM225_RS01410 (QM225_000282) 249196..251364 + 2169 WP_000426225.1 Tex family protein -
QM225_RS01415 (QM225_000283) 251422..251538 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
QM225_RS01420 (QM225_000284) 251734..252192 + 459 WP_000344248.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T282514 WP_000635963.1 NZ_CP125989:248778-249128 [Bacillus cereus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT282514 WP_000004570.1 NZ_CP125989:248486-248773 [Bacillus cereus]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References