Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 161781..162474 Replicon plasmid unnamed
Accession NZ_CP125985
Organism Pseudomonas rhodesiae strain 3.8

Toxin (Protein)


Gene name tad Uniprot ID A0A0D9A9G0
Locus tag QMY54_RS00905 Protein ID WP_042933781.1
Coordinates 161781..162158 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag QMY54_RS00910 Protein ID WP_001172026.1
Coordinates 162139..162474 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMY54_RS00890 (QMY54_00176) 156892..157737 - 846 WP_003464995.1 AraC family transcriptional regulator -
QMY54_RS00895 (QMY54_00177) 157974..161003 - 3030 WP_010799689.1 Tn3 family transposase -
QMY54_RS00900 (QMY54_00178) 160987..161589 - 603 WP_010465829.1 recombinase family protein -
QMY54_RS00905 (QMY54_00179) 161781..162158 + 378 WP_042933781.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMY54_RS00910 (QMY54_00180) 162139..162474 + 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
QMY54_RS00915 (QMY54_00181) 162489..162824 + 336 WP_000741275.1 hypothetical protein -
QMY54_RS00920 (QMY54_00182) 162848..163174 + 327 WP_000091614.1 hypothetical protein -
QMY54_RS00925 (QMY54_00183) 163171..163551 + 381 WP_001054412.1 hypothetical protein -
QMY54_RS00930 (QMY54_00184) 163708..164962 + 1255 Protein_185 HD-GYP domain-containing protein -
QMY54_RS00935 (QMY54_00186) 165865..166101 - 237 WP_078465740.1 hypothetical protein -
QMY54_RS00940 (QMY54_00187) 166186..166761 - 576 WP_078465739.1 hypothetical protein -
QMY54_RS00945 167043..167204 + 162 WP_161952140.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..514920 514920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13735.81 Da        Isoelectric Point: 9.4693

>T282508 WP_042933781.1 NZ_CP125985:161781-162158 [Pseudomonas rhodesiae]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGTGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT282508 WP_001172026.1 NZ_CP125985:162139-162474 [Pseudomonas rhodesiae]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D9A9G0

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References