Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 901240..901716 Replicon chromosome
Accession NC_018608
Organism Staphylococcus aureus 08BA02176

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag C248_RS04395 Protein ID WP_000052076.1
Coordinates 901240..901428 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag C248_RS04400 Protein ID WP_001059690.1
Coordinates 901456..901716 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C248_RS04365 897269..897751 + 483 WP_000824489.1 hypothetical protein -
C248_RS04370 898092..898778 + 687 WP_001574556.1 thermonuclease family protein -
C248_RS04375 899135..899335 + 201 WP_001059082.1 cold-shock protein -
C248_RS04380 899832..900050 - 219 WP_000005881.1 hypothetical protein -
C248_RS04385 900111..900395 - 285 WP_001004403.1 hypothetical protein -
C248_RS04390 900483..901052 - 570 WP_001106655.1 hypothetical protein -
C248_RS04395 901240..901428 - 189 WP_000052076.1 hypothetical protein Toxin
C248_RS04400 901456..901716 - 261 WP_001059690.1 hypothetical protein Antitoxin
C248_RS04405 902060..902263 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
C248_RS04410 902260..902496 - 237 WP_000368687.1 hypothetical protein -
C248_RS04415 902721..903301 + 581 Protein_849 histidine phosphatase family protein -
C248_RS04420 903374..903991 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
C248_RS04425 904140..904634 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
C248_RS04430 905033..905455 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
C248_RS04435 905603..906319 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-258)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-50)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T28250 WP_000052076.1 NC_018608:c901428-901240 [Staphylococcus aureus 08BA02176]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T28250 NC_018608:c901428-901240 [Staphylococcus aureus 08BA02176]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT28250 WP_001059690.1 NC_018608:c901716-901456 [Staphylococcus aureus 08BA02176]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT28250 NC_018608:c901716-901456 [Staphylococcus aureus 08BA02176]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References