Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 892232..892821 Replicon chromosome
Accession NZ_CP125957
Organism Pseudomonas sp. G2-4

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QNH97_RS03835 Protein ID WP_283555673.1
Coordinates 892570..892821 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QNH97_RS03830 Protein ID WP_283555672.1
Coordinates 892232..892573 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNH97_RS03805 (QNH97_03805) 887982..888383 + 402 WP_283555669.1 30S ribosome-binding factor RbfA -
QNH97_RS03810 (QNH97_03810) 888387..889304 + 918 WP_283555670.1 tRNA pseudouridine(55) synthase TruB -
QNH97_RS03815 (QNH97_03815) 889444..889713 + 270 WP_003176135.1 30S ribosomal protein S15 -
QNH97_RS03820 (QNH97_03820) 889907..892012 + 2106 WP_283555671.1 polyribonucleotide nucleotidyltransferase -
QNH97_RS03830 (QNH97_03830) 892232..892573 - 342 WP_283555672.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QNH97_RS03835 (QNH97_03835) 892570..892821 - 252 WP_283555673.1 type II toxin-antitoxin system HicA family toxin Toxin
QNH97_RS03840 (QNH97_03840) 893182..893487 + 306 WP_283555674.1 DUF6388 family protein -
QNH97_RS03845 (QNH97_03845) 893527..894375 - 849 WP_283555675.1 carboxylating nicotinate-nucleotide diphosphorylase -
QNH97_RS03850 (QNH97_03850) 894644..896857 + 2214 WP_283555676.1 DUF1631 domain-containing protein -
QNH97_RS03855 (QNH97_03855) 896922..897482 + 561 WP_283555677.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9260.75 Da        Isoelectric Point: 10.3202

>T282495 WP_283555673.1 NZ_CP125957:c892821-892570 [Pseudomonas sp. G2-4]
MSKNEKLLAKLLNGQSTFTWSELVTLLCRLGYSHLEGSGSRVKFDNGNPSAMINLHKPHPGNELKAYIRRQIIEQLKTGG
LIP

Download         Length: 252 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12613.25 Da        Isoelectric Point: 5.5558

>AT282495 WP_283555672.1 NZ_CP125957:c892573-892232 [Pseudomonas sp. G2-4]
MSAQLQYKGYVGSIEASTEDKCLFGKLLFIRALVSYEGQTVAELEEAFREAIDDYLQTCQQLGQKPEIPCKGSFNVRIGH
DLHLAAALAATRQNVSLNDLTRQALNEYLQHHA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References