Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5048681..5050368 Replicon chromosome
Accession NZ_CP125947
Organism Comamonas sp. ZM22

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag QMY55_RS23600 Protein ID WP_283486508.1
Coordinates 5049484..5050368 (-) Length 295 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag QMY55_RS23595 Protein ID WP_283486507.1
Coordinates 5048681..5049487 (-) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMY55_RS23570 (QMY55_23570) 5043778..5044635 - 858 WP_283486502.1 IclR family transcriptional regulator -
QMY55_RS23575 (QMY55_23575) 5044649..5045425 - 777 WP_283486503.1 SDR family oxidoreductase -
QMY55_RS23580 (QMY55_23580) 5045768..5046505 - 738 WP_283486504.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
QMY55_RS23585 (QMY55_23585) 5046601..5047599 - 999 WP_283486505.1 tripartite tricarboxylate transporter substrate binding protein -
QMY55_RS23590 (QMY55_23590) 5047795..5048595 - 801 WP_283486506.1 aspartate dehydrogenase -
QMY55_RS23595 (QMY55_23595) 5048681..5049487 - 807 WP_283486507.1 IclR family transcriptional regulator Antitoxin
QMY55_RS23600 (QMY55_23600) 5049484..5050368 - 885 WP_283486508.1 alpha/beta hydrolase Toxin
QMY55_RS23605 (QMY55_23605) 5050377..5050907 - 531 WP_283486509.1 cupin domain-containing protein -
QMY55_RS23610 (QMY55_23610) 5051123..5052799 - 1677 WP_283486510.1 long-chain-fatty-acid--CoA ligase -
QMY55_RS23615 (QMY55_23615) 5052897..5053364 - 468 WP_283486511.1 helix-turn-helix domain-containing protein -
QMY55_RS23620 (QMY55_23620) 5053509..5054573 - 1065 WP_283486512.1 fructose-bisphosphate aldolase class II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(44-276)

Antitoxin

Transcription regulator IclR, C-terminal

(137-257)


Sequences

Toxin        


Download         Length: 295 a.a.        Molecular weight: 30541.86 Da        Isoelectric Point: 6.8489

>T282491 WP_283486508.1 NZ_CP125947:c5050368-5049484 [Comamonas sp. ZM22]
MTQDTLSFKVQQLQAGFPERLVQLPDGSRVAWREAGDATDEFAVVLLHGISSGAASWLDLALALGDKARVLAWDAPGYGV
STPLAQPTPGDADYARALEQSLQALGVRRCLLVGHSLGALMAARLAGTASGLVEQLVLISPAGGYGAPAKAEQQAKVRQG
RLAALAGKGVAGLAAVIDQRLVSAEAPESVRAWVRWNTARMQPQGYAQAVELLCGGDLGQAAGKLSMPVQVWVGEHDVVT
PPAACKAWSELLGADYGTLAAAGHASPVEQPVAIAQKLASLLNQSTRTSTCRQP

Download         Length: 885 bp

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29046.02 Da        Isoelectric Point: 4.8240

>AT282491 WP_283486507.1 NZ_CP125947:c5049487-5048681 [Comamonas sp. ZM22]
MSDTSEISTNDNDRYTVPALERGLRLLACFGPVQPVWSAPELARCLQLPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQGLCDALGMTSNLALLDGTSVVYVARIAPPGAFQGAVRVGSRLPAHATVLGRTLLQDMDA
AQLRELFGGEELPQFSESTPRHVEDLASLLAQDRERGYAMGEGFYEPSVSSIAAPVRGGSGQVVAGLAVAIPFTELVPEK
TQLWAQQVQEAAETLSAHLRQQHPDLLR

Download         Length: 807 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References