Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2486335..2487868 Replicon chromosome
Accession NZ_CP125947
Organism Comamonas sp. ZM22

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag QMY55_RS11580 Protein ID WP_283488735.1
Coordinates 2486585..2487868 (+) Length 428 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag QMY55_RS11575 Protein ID WP_283488734.1
Coordinates 2486335..2486595 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMY55_RS11560 (QMY55_11560) 2481982..2482173 + 192 WP_283488731.1 hypothetical protein -
QMY55_RS11565 (QMY55_11565) 2482523..2483575 - 1053 WP_283488732.1 hypothetical protein -
QMY55_RS11570 (QMY55_11570) 2483526..2485427 - 1902 WP_283488733.1 DUF3696 domain-containing protein -
QMY55_RS11575 (QMY55_11575) 2486335..2486595 + 261 WP_283488734.1 helix-turn-helix transcriptional regulator Antitoxin
QMY55_RS11580 (QMY55_11580) 2486585..2487868 + 1284 WP_283488735.1 type II toxin-antitoxin system HipA family toxin Toxin
QMY55_RS11585 (QMY55_11585) 2488137..2488376 - 240 WP_283488736.1 hypothetical protein -
QMY55_RS11590 (QMY55_11590) 2488762..2490132 - 1371 WP_283488737.1 MFS transporter -
QMY55_RS11595 (QMY55_11595) 2490763..2491119 - 357 WP_283488738.1 zinc ribbon domain-containing protein YjdM -
QMY55_RS11600 (QMY55_11600) 2491323..2492234 - 912 WP_283488739.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(153-387)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-60)


Sequences

Toxin        


Download         Length: 428 a.a.        Molecular weight: 46781.74 Da        Isoelectric Point: 6.8200

>T282489 WP_283488735.1 NZ_CP125947:2486585-2487868 [Comamonas sp. ZM22]
MAHELEVWLFERRVGSLSLVHGRLSFAYAPDLLVLPQATALSQSLPLQAESFDDHQTRPFFAGLLPEGQMRRLIAQQFQV
SGQNDFALLDHIGGECAGAVTFLEPGQALPQINGAGSTGVEGDVEWLSDEKLIALLDELPRRPMLAGDDGLRLSLAGAQD
KLPVVFDGQRFGLPRNGAPSSHILKPAIHAVEDSVSNEGFCMLLAEVMGLRPANARIHSVLGRSFLLVERYDRVLKGDAQ
HQPQLQRLHQEDFCQALGVVPEMKYQNEGGPGLAQCFALLRSVTRPSAPQVLRLLDGVIFNALIGNHDAHGKNFSLLYGG
RSPALAPFYDLLATAIYPQLTPKMAMKIGSKYKFSELEAKHWEQFAEESGLAKAATRRRLQQLATELPLAARKLQAAPQH
GFAGNAVVEQIVQLIEQRCALTLRRMG

Download         Length: 1284 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 8806.01 Da        Isoelectric Point: 5.5332

>AT282489 WP_283488734.1 NZ_CP125947:2486335-2486595 [Comamonas sp. ZM22]
MSTIHTADQLGTAVRTARKQLGLTQPQLALAAGVGTRFIVDLEAGKPTVRLEHVLRVIDALGGELQLGGLPDPASEGVAE
GADHGA

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References