Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/GNAT-DUF1778
Location 1644437..1645215 Replicon chromosome
Accession NZ_CP125947
Organism Comamonas sp. ZM22

Toxin (Protein)


Gene name tacT Uniprot ID A0A0M4L1V5
Locus tag QMY55_RS07595 Protein ID WP_053821302.1
Coordinates 1644712..1645215 (+) Length 168 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H4W2N5
Locus tag QMY55_RS07590 Protein ID WP_029577227.1
Coordinates 1644437..1644715 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMY55_RS07570 (QMY55_07570) 1641496..1642137 + 642 WP_283488038.1 OmpA family protein -
QMY55_RS07575 (QMY55_07575) 1642223..1642936 + 714 WP_283488039.1 bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG -
QMY55_RS07580 (QMY55_07580) 1642942..1643607 + 666 WP_283488904.1 phosphoglycolate phosphatase -
QMY55_RS07590 (QMY55_07590) 1644437..1644715 + 279 WP_029577227.1 DUF1778 domain-containing protein Antitoxin
QMY55_RS07595 (QMY55_07595) 1644712..1645215 + 504 WP_053821302.1 GNAT family N-acetyltransferase Toxin
QMY55_RS07600 (QMY55_07600) 1645231..1645662 - 432 WP_283488040.1 LacI family transcriptional regulator -
QMY55_RS07605 (QMY55_07605) 1645659..1647014 - 1356 WP_283488041.1 recombinase family protein -
QMY55_RS07610 (QMY55_07610) 1647011..1647517 - 507 WP_222228008.1 DUF2924 domain-containing protein -
QMY55_RS07615 (QMY55_07615) 1647514..1647732 - 219 WP_283488042.1 hypothetical protein -
QMY55_RS07620 (QMY55_07620) 1647858..1649072 - 1215 WP_151022076.1 hypothetical protein -
QMY55_RS07625 (QMY55_07625) 1649090..1649980 - 891 WP_249041645.1 ImmA/IrrE family metallo-endopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1638561..1688536 49975


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-145)

Antitoxin

Vibrio phage ICP1, Orf50

(11-86)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 18409.16 Da        Isoelectric Point: 7.2632

>T282487 WP_053821302.1 NZ_CP125947:1644712-1645215 [Comamonas sp. ZM22]
MSNDYSPVRKLAATDQVDAFDCGQAALNQFLQRYALVNQKANSAQTYVCCQGDVVVGFYSLAVGSVDPEATPSRVMKGLA
RHPVPVMILARLAVDKEHQRKGLGQALLKDALLRTAQAADIAGIRCLLVHAKDDAARQWYESWEFDPSPTDPYHLFLMLK
DLKGMLS

Download         Length: 504 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10344.85 Da        Isoelectric Point: 9.2519

>AT282487 WP_029577227.1 NZ_CP125947:1644437-1644715 [Comamonas sp. ZM22]
MSTLNLSKTERIDVRASTPVKQLLQEAARACHKNVSEFLLDAGVTAAAQTLADRRQFVLDDTQWQAFQEALDRPVQSKPR
LKKLLREPGVLD

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4L1V5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H4W2N5

References