Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1068849..1069417 Replicon chromosome
Accession NZ_CP125946
Organism Rothia sp. SD9660Na

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QM007_RS05160 Protein ID WP_185174621.1
Coordinates 1069070..1069417 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag QM007_RS05155 Protein ID WP_237206551.1
Coordinates 1068849..1069073 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM007_RS05115 (QM007_05115) 1064125..1065276 + 1152 WP_283490840.1 hypothetical protein -
QM007_RS05120 (QM007_05120) 1065336..1065788 + 453 WP_283490841.1 ribosome silencing factor -
QM007_RS05135 (QM007_05135) 1066311..1066787 + 477 WP_283490842.1 DUF2975 domain-containing protein -
QM007_RS05140 (QM007_05140) 1066784..1067011 + 228 WP_272878551.1 helix-turn-helix transcriptional regulator -
QM007_RS05145 (QM007_05145) 1067133..1067921 - 789 WP_283490843.1 TatD family hydrolase -
QM007_RS05150 (QM007_05150) 1067923..1068726 - 804 WP_283490845.1 tRNA threonylcarbamoyladenosine dehydratase -
QM007_RS05155 (QM007_05155) 1068849..1069073 + 225 WP_237206551.1 ribbon-helix-helix domain-containing protein Antitoxin
QM007_RS05160 (QM007_05160) 1069070..1069417 + 348 WP_185174621.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QM007_RS05165 (QM007_05165) 1070748..1071992 + 1245 WP_283489550.1 IS256 family transposase -
QM007_RS05170 (QM007_05170) 1072058..1072564 + 507 WP_283490846.1 hypothetical protein -
QM007_RS05175 (QM007_05175) 1072915..1073385 - 471 WP_283490847.1 DUF3817 domain-containing protein -
QM007_RS05180 (QM007_05180) 1073631..1073978 + 348 WP_283490848.1 hypothetical protein -
QM007_RS05185 (QM007_05185) 1074046..1074396 + 351 WP_283490849.1 DUF2200 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-39)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12897.57 Da        Isoelectric Point: 6.7269

>T282485 WP_185174621.1 NZ_CP125946:1069070-1069417 [Rothia sp. SD9660Na]
MRRGDVYWVDFEPARGSEPNKKRPAIIVSRDESNTYVAHHGIGTLTVVPLTSNTRFIASFQVLLAQDETGLSTDSKAQTE
LIRTVSVDRIGDYIGTLSRNKVWELDEALKVHLNL

Download         Length: 348 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8163.99 Da        Isoelectric Point: 4.2813

>AT282485 WP_237206551.1 NZ_CP125946:1068849-1069073 [Rothia sp. SD9660Na]
MTTKISISLADETVEALDRFIAQRKFASRSSAIKAAIDQMTSVDLTDEYARAHREWAESGEEDVWGQTSGDGLV

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References