Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2253471..2253985 Replicon chromosome
Accession NZ_CP125903
Organism Staphylococcus aureus strain CHAL1

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag QM337_RS11305 Protein ID WP_000581791.1
Coordinates 2253471..2253680 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag QM337_RS11310 Protein ID WP_000138934.1
Coordinates 2253692..2253985 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM337_RS11285 (2249389) 2249389..2250459 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
QM337_RS11290 (2250777) 2250777..2251979 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
QM337_RS11295 (2252140) 2252140..2252823 - 684 Protein_2186 transposase -
QM337_RS11300 (2253206) 2253206..2253343 - 138 WP_000828354.1 Lmo0850 family protein -
QM337_RS11305 (2253471) 2253471..2253680 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
QM337_RS11310 (2253692) 2253692..2253985 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
QM337_RS11315 (2254151) 2254151..2255635 + 1485 WP_283531614.1 cardiolipin synthase -
QM337_RS11320 (2255663) 2255663..2256310 + 648 WP_001187612.1 HD domain-containing protein -
QM337_RS11325 (2256923) 2256923..2257795 - 873 WP_000725802.1 membrane protein insertase YidC -
QM337_RS11330 (2257881) 2257881..2258522 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T282478 WP_000581791.1 NZ_CP125903:c2253680-2253471 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT282478 WP_000138934.1 NZ_CP125903:c2253985-2253692 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References