Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2019430..2020206 Replicon chromosome
Accession NZ_CP125903
Organism Staphylococcus aureus strain CHAL1

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag QM337_RS09870 Protein ID WP_000031108.1
Coordinates 2019430..2019582 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag QM337_RS09875 Protein ID WP_001251219.1
Coordinates 2019607..2020206 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM337_RS09855 (2015576) 2015576..2016397 + 822 WP_000669380.1 RluA family pseudouridine synthase -
QM337_RS09860 (2016853) 2016853..2018238 - 1386 WP_000116227.1 class II fumarate hydratase -
QM337_RS09865 (2018434) 2018434..2018829 - 396 WP_000901019.1 hypothetical protein -
QM337_RS09870 (2019430) 2019430..2019582 - 153 WP_000031108.1 SAS053 family protein Toxin
QM337_RS09875 (2019607) 2019607..2020206 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
QM337_RS09880 (2020365) 2020365..2020835 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QM337_RS09885 (2020840) 2020840..2021967 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
QM337_RS09890 (2022118) 2022118..2022840 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
QM337_RS09895 (2022833) 2022833..2024290 - 1458 WP_000649898.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T282472 WP_000031108.1 NZ_CP125903:c2019582-2019430 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT282472 WP_001251219.1 NZ_CP125903:c2020206-2019607 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References